Integrated machine learning for cause-of-death classification and postmortem interval prediction: Liver and kidney metabolomics from seawater-immersed rat cadavers

Jianghuan Lu; Yuzhao Xu; Siqi Chen; Zhiao Duan; Yixin Ma; Xiaoshi Qin; Yunchao Zhou; Shan Ha; Jianhua Chen; Jianqiang Deng

doi:10.1371/journal.pone.0353958

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Open Access

Peer-reviewed

Research Article

Integrated machine learning for cause-of-death classification and postmortem interval prediction: Liver and kidney metabolomics from seawater-immersed rat cadavers

Jianghuan Lu ,

Contributed equally to this work with: Jianghuan Lu, Yuzhao Xu, Siqi Chen

Roles Formal analysis, Investigation, Visualization, Writing – original draft

Affiliations Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medical Sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China, Department of Forensic Medicine & Hainan Provincial Tropical Forensic Engineering Research Center & Hainan Provincial Tropical Forensic Academician Workstation, School of Basic Medical Sciences, Hainan Medical University, Haikou, China
⨯
Yuzhao Xu ,

Contributed equally to this work with: Jianghuan Lu, Yuzhao Xu, Siqi Chen

Roles Formal analysis, Data curation, Methodology, Visualization

Affiliations Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medical Sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China, Department of Forensic Medicine & Hainan Provincial Tropical Forensic Engineering Research Center & Hainan Provincial Tropical Forensic Academician Workstation, School of Basic Medical Sciences, Hainan Medical University, Haikou, China
⨯
Siqi Chen ,

Contributed equally to this work with: Jianghuan Lu, Yuzhao Xu, Siqi Chen

Roles Data curation, Investigation, Validation, Writing – review & editing

Affiliations Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medical Sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China, Department of Forensic Medicine & Hainan Provincial Tropical Forensic Engineering Research Center & Hainan Provincial Tropical Forensic Academician Workstation, School of Basic Medical Sciences, Hainan Medical University, Haikou, China
⨯
Zhiao Duan,

Roles Investigation, Validation

Affiliations Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medical Sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China, Department of Forensic Medicine & Hainan Provincial Tropical Forensic Engineering Research Center & Hainan Provincial Tropical Forensic Academician Workstation, School of Basic Medical Sciences, Hainan Medical University, Haikou, China
⨯
Yixin Ma,

Roles Validation

Affiliations Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medical Sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China, Department of Forensic Medicine & Hainan Provincial Tropical Forensic Engineering Research Center & Hainan Provincial Tropical Forensic Academician Workstation, School of Basic Medical Sciences, Hainan Medical University, Haikou, China
⨯
Xiaoshi Qin,

Roles Validation

Affiliations Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medical Sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China, Department of Forensic Medicine & Hainan Provincial Tropical Forensic Engineering Research Center & Hainan Provincial Tropical Forensic Academician Workstation, School of Basic Medical Sciences, Hainan Medical University, Haikou, China
⨯
Yunchao Zhou,

Roles Supervision

Affiliations Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medical Sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China, Department of Forensic Medicine & Hainan Provincial Tropical Forensic Engineering Research Center & Hainan Provincial Tropical Forensic Academician Workstation, School of Basic Medical Sciences, Hainan Medical University, Haikou, China
⨯
Shan Ha,

Roles Investigation

Affiliations Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medical Sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China, Department of Forensic Medicine & Hainan Provincial Tropical Forensic Engineering Research Center & Hainan Provincial Tropical Forensic Academician Workstation, School of Basic Medical Sciences, Hainan Medical University, Haikou, China
⨯
Jianhua Chen ,

Roles Methodology, Writing – review & editing

* E-mail: cjhtin86591@163.com (JC); forensicpatho@163.com (JD)

Affiliations Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medical Sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China, Department of Forensic Medicine & Hainan Provincial Tropical Forensic Engineering Research Center & Hainan Provincial Tropical Forensic Academician Workstation, School of Basic Medical Sciences, Hainan Medical University, Haikou, China
⨯
Jianqiang Deng

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – review & editing

* E-mail: cjhtin86591@163.com (JC); forensicpatho@163.com (JD)

Affiliations Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medical Sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China, Department of Forensic Medicine & Hainan Provincial Tropical Forensic Engineering Research Center & Hainan Provincial Tropical Forensic Academician Workstation, School of Basic Medical Sciences, Hainan Medical University, Haikou, China

https://orcid.org/0000-0002-2156-0520

⨯

Integrated machine learning for cause-of-death classification and postmortem interval prediction: Liver and kidney metabolomics from seawater-immersed rat cadavers

Jianghuan Lu,
Yuzhao Xu,
Siqi Chen,
Zhiao Duan,
Yixin Ma,
Xiaoshi Qin,
Yunchao Zhou,
Shan Ha,
Jianhua Chen,
Jianqiang Deng

Published: July 23, 2026
https://doi.org/10.1371/journal.pone.0353958

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