HLA-DRB1 and HLA-DQB1 genetic polymorphisms and susceptibility to coronary atherosclerosis in a Northeast Chinese Population: A case-control study

Miaomiao Niu; Jing Gao; Xiaodong Han; Ying Dong; Hui Wang; Yue Zhang; Dongming Zhao; Zijian Wang; Fang Qi; Feng Wang; Qiuye Meng; Jinjiao Geng; Shuqi Wu; Ying Wang; Ying Zhang; Chaoyang Guo; Hua Chen

doi:10.1371/journal.pone.0353906

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Open Access

Peer-reviewed

Research Article

HLA-DRB1 and HLA-DQB1 genetic polymorphisms and susceptibility to coronary atherosclerosis in a Northeast Chinese Population: A case-control study

Miaomiao Niu,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft

Affiliation Medical Innovation Research Department, Chinese PLA General Hospital, Beijing, China
⨯
Jing Gao,

Roles Data curation

Affiliation Department of Cardiology, Liaoyuan municipal central hospital of Jilin Province, Jilin, China
⨯
Xiaodong Han,

Roles Data curation

Affiliation Department of Cardiology, Liaoyuan municipal central hospital of Jilin Province, Jilin, China
⨯
Ying Dong,

Roles Conceptualization

Affiliation Department of Cardiology, Liaoyuan municipal central hospital of Jilin Province, Jilin, China
⨯
Hui Wang,

Roles Data curation

Affiliation Department of Cardiology, Liaoyuan municipal central hospital of Jilin Province, Jilin, China
⨯
Yue Zhang,

Roles Data curation

Affiliation Department of Cardiology, Liaoyuan municipal central hospital of Jilin Province, Jilin, China
⨯
Dongming Zhao,

Roles Data curation

Affiliation Department of Cardiology, Liaoyuan municipal central hospital of Jilin Province, Jilin, China
⨯
Zijian Wang,

Roles Data curation

Affiliation Department of Cardiology, Liaoyuan municipal central hospital of Jilin Province, Jilin, China
⨯
Fang Qi,

Roles Data curation

Affiliation Department of Cardiology, Liaoyuan municipal central hospital of Jilin Province, Jilin, China
⨯
Feng Wang,

Roles Data curation

Affiliation Department of Cardiology, Liaoyuan municipal central hospital of Jilin Province, Jilin, China
⨯
Qiuye Meng,

Roles Data curation

Affiliation Department of Cardiology, Liaoyuan municipal central hospital of Jilin Province, Jilin, China
⨯
Jinjiao Geng,

Roles Data curation

Affiliation Department of Cardiology, Liaoyuan municipal central hospital of Jilin Province, Jilin, China
⨯
Shuqi Wu,

Roles Data curation

Affiliation Department of Cardiology, Liaoyuan municipal central hospital of Jilin Province, Jilin, China
⨯
Ying Wang,

Roles Data curation

Affiliation Department of Cardiology, Liaoyuan municipal central hospital of Jilin Province, Jilin, China
⨯
Ying Zhang,

Roles Data curation

Affiliation Department of Cardiology, Liaoyuan municipal central hospital of Jilin Province, Jilin, China
⨯
Chaoyang Guo ,

Roles Data curation, Supervision, Visualization

* E-mail: chenhua301paper@163.com (HC), gcy9385@163.com (CG)

Affiliation Department of Cardiology, Liaoyuan municipal central hospital of Jilin Province, Jilin, China
⨯
[ ... ],
Hua Chen

Roles Conceptualization, Funding acquisition, Visualization, Writing – review & editing

* E-mail: chenhua301paper@163.com (HC), gcy9385@163.com (CG)

Affiliation Medical Innovation Research Department, Chinese PLA General Hospital, Beijing, China

https://orcid.org/0000-0003-0110-2933

⨯
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HLA-DRB1 and HLA-DQB1 genetic polymorphisms and susceptibility to coronary atherosclerosis in a Northeast Chinese Population: A case-control study

Miaomiao Niu,
Jing Gao,
Xiaodong Han,
Ying Dong,
Hui Wang,
Yue Zhang,
Dongming Zhao,
Zijian Wang,
Fang Qi,
Feng Wang

Published: July 23, 2026
https://doi.org/10.1371/journal.pone.0353906

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