Integrative multi-omics and machine learning identify CHRNA1 putative circadian-immune hub in COPD

Lan Zhang; Zhifei Li; Tiansheng Xia; Tingting Yang; Jia Fu; Yan Lu; Jiayi Xu; Kaiyu Han

doi:10.1371/journal.pone.0353838

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Open Access

Peer-reviewed

Research Article

Integrative multi-omics and machine learning identify CHRNA1 putative circadian-immune hub in COPD

Lan Zhang ,

Contributed equally to this work with: Lan Zhang, Zhifei Li

Roles Formal analysis, Software, Validation, Visualization, Writing – original draft

Affiliation Department of Respiratory and Critical Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
⨯
Zhifei Li ,

Contributed equally to this work with: Lan Zhang, Zhifei Li

Roles Software, Validation, Visualization

Affiliation Department of Respiratory and Critical Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
⨯
Tiansheng Xia,

Roles Software, Validation, Visualization

Affiliation Department of Respiratory and Critical Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
⨯
Tingting Yang,

Roles Validation, Visualization

Affiliation Department of Respiratory and Critical Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
⨯
Jia Fu,

Roles Validation, Visualization

Affiliation Department of Respiratory and Critical Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
⨯
Yan Lu,

Roles Conceptualization, Validation, Visualization

Affiliation Department of Respiratory and Critical Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
⨯
Jiayi Xu ,

Roles Data curation, Methodology, Validation, Writing – review & editing

* E-mail: hankaiyu2002@163.com (KH); jiayixu.jy@foxmail.com (JX)

Affiliation Department of Respiratory and Critical Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China

https://orcid.org/0009-0003-9294-8615

⨯
Kaiyu Han

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: hankaiyu2002@163.com (KH); jiayixu.jy@foxmail.com (JX)

Affiliation Department of Respiratory and Critical Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
⨯

Integrative multi-omics and machine learning identify CHRNA1 putative circadian-immune hub in COPD

Lan Zhang,
Zhifei Li,
Tiansheng Xia,
Tingting Yang,
Jia Fu,
Yan Lu,
Jiayi Xu,
Kaiyu Han

Published: July 31, 2026
https://doi.org/10.1371/journal.pone.0353838

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Chronic obstructive pulmonary disease
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Circadian rhythms
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Immune cells
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Gene expression
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Medical risk factors
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Circadian oscillators
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Transcriptome analysis
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