N-acetyl-L-leucine normalizes Transcription Factor EB activity by stereospecific bidirectional modulation in a HeLa cell model of Niemann-Pick disease type C

• Lianne C. Davis,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft

  Affiliation Department of Pharmacology, University of Oxford, Oxford, United Kingdom

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• Wim Annaert,

  Roles Conceptualization, Resources, Writing – review & editing

  Affiliation VIB Center for Neuroscience Leuven & Department of Neurosciences, Laboratory for Membrane Trafficking, Leuven, Belgium

  https://orcid.org/0000-0003-0150-9661

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• Rebecca Braine,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pharmacology, University of Oxford, Oxford, United Kingdom

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• Grant C. Churchill,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft

  Affiliation Department of Pharmacology, University of Oxford, Oxford, United Kingdom

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• Mallory Factor,

  Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

  Affiliations Department of Pharmacology, University of Oxford, Oxford, United Kingdom, IntraBio Inc, Austin, United States of America

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• Taylor Fields,

  Roles Funding acquisition, Investigation, Writing – review & editing, Conceptualization

  Affiliation IntraBio Inc, Austin, United States of America

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• Marc Patterson,

  Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation IntraBio Inc, Austin, United States of America

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• Frances Platt,

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Writing – review & editing

  Affiliation Department of Pharmacology, University of Oxford, Oxford, United Kingdom

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• Dawn Shepherd,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Pharmacology, University of Oxford, Oxford, United Kingdom

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• Michael Strupp,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Department of Neurology, LMU University Hospital, LMU Munich, Munich, Germany

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• Antony Galione

  Roles Conceptualization, Funding acquisition, Investigation, Writing – original draft

  * E-mail: antony.galione@pharm.ox.ac.uk

  Affiliation Department of Pharmacology, University of Oxford, Oxford, United Kingdom

  https://orcid.org/0000-0002-4132-7646

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