Comparative clinical outcomes of polymyxin-based versus non-polymyxin regimens as definitive therapy in Carbapenem-resistant Klebsiella pneumoniae bacteraemia

Divya Bhat; Asha K. Rajan; Vandana Kalwaje Eshwara; Muralidhar Varma; Shashikiran Umakanth; Girish Thunga; Vishal Shanbhag

doi:10.1371/journal.pone.0353799

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Open Access

Peer-reviewed

Research Article

Comparative clinical outcomes of polymyxin-based versus non-polymyxin regimens as definitive therapy in Carbapenem-resistant Klebsiella pneumoniae bacteraemia

Divya Bhat ,

Contributed equally to this work with: Divya Bhat, Asha K. Rajan

Roles Conceptualization, Data curation, Project administration, Writing – original draft, Writing – review & editing

Affiliation Department of Critical Care Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
⨯
Asha K. Rajan ,

Contributed equally to this work with: Divya Bhat, Asha K. Rajan

Roles Conceptualization, Project administration, Software, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmacy Practice Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India

https://orcid.org/0000-0002-8523-7968

⨯
Vandana Kalwaje Eshwara,

Roles Resources, Supervision, Writing – review & editing

Affiliation Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
⨯
Muralidhar Varma,

Roles Supervision, Writing – review & editing

Affiliation Department of Infectious Diseases, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
⨯
Shashikiran Umakanth,

Roles Supervision, Writing – review & editing

Affiliation Department of General Medicine, Dr. TMA Pai Hospital, Udupi, Karnataka, India
⨯
Girish Thunga,

Roles Supervision, Writing – review & editing

Affiliation Department of Pharmacy Practice Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India
⨯
Vishal Shanbhag

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: vishal.shanbhag@manipal.edu

Affiliation Department of Critical Care Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India

https://orcid.org/0000-0001-5255-6148

⨯

Comparative clinical outcomes of polymyxin-based versus non-polymyxin regimens as definitive therapy in Carbapenem-resistant Klebsiella pneumoniae bacteraemia

Divya Bhat,
Asha K. Rajan,
Vandana Kalwaje Eshwara,
Muralidhar Varma,
Shashikiran Umakanth,
Girish Thunga,
Vishal Shanbhag

Published: July 15, 2026
https://doi.org/10.1371/journal.pone.0353799

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