CDCA8 regulates ATP5F1A protein stability and malignant phenotypes in wilms tumor cells: Prognostic implications and mechanistic insights

Qiang Zeng; Junfeng Tao; Guangbei Peng; Lilu Qin; Shuzhen Wu; Chen Wang; Zhong Liu; Linshan Zeng

doi:10.1371/journal.pone.0353696

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Open Access

Peer-reviewed

Research Article

CDCA8 regulates ATP5F1A protein stability and malignant phenotypes in wilms tumor cells: Prognostic implications and mechanistic insights

Qiang Zeng ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

¶‡ These authors share first author on this work.

Affiliation Department of Pediatric Surgery, Jiangxi Maternal and Child Health Hospital, Jiangxi Children’s Medical Center, Nanchang, Jiangxi, P. R. China
⨯
Junfeng Tao ,

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Software, Writing – original draft, Writing – review & editing

¶‡ These authors share first author on this work.

Affiliation Department of Pediatric Surgery, Jiangxi Maternal and Child Health Hospital, Jiangxi Children’s Medical Center, Nanchang, Jiangxi, P. R. China
⨯
Guangbei Peng,

Roles Conceptualization, Formal analysis, Methodology, Software, Validation, Visualization

Affiliation Department of Pediatric Surgery, Jiangxi Maternal and Child Health Hospital, Jiangxi Children’s Medical Center, Nanchang, Jiangxi, P. R. China
⨯
Lilu Qin,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization

Affiliation Department of Pediatric Surgery, Jiangxi Maternal and Child Health Hospital, Jiangxi Children’s Medical Center, Nanchang, Jiangxi, P. R. China
⨯
Shuzhen Wu,

Roles Formal analysis, Investigation, Methodology, Software, Validation

Affiliation Department of Pediatric Surgery, Jiangxi Maternal and Child Health Hospital, Jiangxi Children’s Medical Center, Nanchang, Jiangxi, P. R. China
⨯
Chen Wang,

Roles Formal analysis, Methodology, Software, Validation, Visualization

Affiliation Department of Pediatric Surgery, Jiangxi Maternal and Child Health Hospital, Jiangxi Children’s Medical Center, Nanchang, Jiangxi, P. R. China
⨯
Zhong Liu,

Roles Formal analysis, Investigation, Methodology, Software, Validation, Visualization

Affiliation Department of Pediatric Surgery, Jiangxi Maternal and Child Health Hospital, Jiangxi Children’s Medical Center, Nanchang, Jiangxi, P. R. China
⨯
Linshan Zeng

Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

* E-mail: zlsed1216@163.com

Affiliation Department of Pediatric Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, P. R. China

https://orcid.org/0009-0004-3542-7079

⨯

CDCA8 regulates ATP5F1A protein stability and malignant phenotypes in wilms tumor cells: Prognostic implications and mechanistic insights

Qiang Zeng,
Junfeng Tao,
Guangbei Peng,
Lilu Qin,
Shuzhen Wu,
Chen Wang,
Zhong Liu,
Linshan Zeng

Published: July 21, 2026
https://doi.org/10.1371/journal.pone.0353696

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