Exploring the mechanism of Shuangyu Granule in regulating immune-inflammatory responses in influenza through UPLC-Orbitrap-MS/MS, GC-MS, and network target analysis

Ling Sun; ZhiTao Jiang; Ying Chen; MingShu Han; YaoZhong Lv; Liang Li; XinZhuang Zhang; Liang Cao; TuanJie Wang; ZhenZhong Wang; Wei Xiao

doi:10.1371/journal.pone.0353259

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Open Access

Peer-reviewed

Research Article

Exploring the mechanism of Shuangyu Granule in regulating immune-inflammatory responses in influenza through UPLC-Orbitrap-MS/MS, GC-MS, and network target analysis

Ling Sun,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Software, Validation, Visualization, Writing – original draft

Affiliations State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (Jiangsu Kanion Pharmaceutical Co., Ltd. & Nanjing University of Chinese Medicine) Jiangsu, Nanjing, China, Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, China
⨯
ZhiTao Jiang,

Roles Formal analysis, Resources

Affiliation State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (Jiangsu Kanion Pharmaceutical Co., Ltd. & Nanjing University of Chinese Medicine) Jiangsu, Nanjing, China
⨯
Ying Chen,

Roles Data curation, Formal analysis, Methodology

Affiliations State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (Jiangsu Kanion Pharmaceutical Co., Ltd. & Nanjing University of Chinese Medicine) Jiangsu, Nanjing, China, Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, China
⨯
MingShu Han,

Roles Data curation, Software

Affiliations State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (Jiangsu Kanion Pharmaceutical Co., Ltd. & Nanjing University of Chinese Medicine) Jiangsu, Nanjing, China, Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, China
⨯
YaoZhong Lv,

Roles Formal analysis, Investigation, Methodology, Resources

Affiliations State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (Jiangsu Kanion Pharmaceutical Co., Ltd. & Nanjing University of Chinese Medicine) Jiangsu, Nanjing, China, Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, China
⨯
Liang Li,

Roles Resources, Software, Supervision, Validation

Affiliations State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (Jiangsu Kanion Pharmaceutical Co., Ltd. & Nanjing University of Chinese Medicine) Jiangsu, Nanjing, China, Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, China
⨯
XinZhuang Zhang,

Roles Resources, Software, Supervision, Validation, Visualization

Affiliations State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (Jiangsu Kanion Pharmaceutical Co., Ltd. & Nanjing University of Chinese Medicine) Jiangsu, Nanjing, China, Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, China
⨯
Liang Cao,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliations State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (Jiangsu Kanion Pharmaceutical Co., Ltd. & Nanjing University of Chinese Medicine) Jiangsu, Nanjing, China, Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, China
⨯
TuanJie Wang,

Roles Resources

Affiliations State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (Jiangsu Kanion Pharmaceutical Co., Ltd. & Nanjing University of Chinese Medicine) Jiangsu, Nanjing, China, Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, China
⨯
ZhenZhong Wang,

Roles Project administration, Resources, Software, Validation

Affiliations State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (Jiangsu Kanion Pharmaceutical Co., Ltd. & Nanjing University of Chinese Medicine) Jiangsu, Nanjing, China, Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, China
⨯
Wei Xiao

Roles Data curation, Formal analysis, Methodology, Resources, Writing – review & editing

* E-mail: xw_kanion@163.com

Affiliations State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (Jiangsu Kanion Pharmaceutical Co., Ltd. & Nanjing University of Chinese Medicine) Jiangsu, Nanjing, China, Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, China

https://orcid.org/0000-0001-8809-9137

⨯

Exploring the mechanism of Shuangyu Granule in regulating immune-inflammatory responses in influenza through UPLC-Orbitrap-MS/MS, GC-MS, and network target analysis

Ling Sun,
ZhiTao Jiang,
Ying Chen,
MingShu Han,
YaoZhong Lv,
Liang Li,
XinZhuang Zhang,
Liang Cao,
TuanJie Wang,
ZhenZhong Wang

Published: July 27, 2026
https://doi.org/10.1371/journal.pone.0353259

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Influenza
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