From gut to pancreas: Shared genetic susceptibility and biological convergence in acute pancreatitis and Crohn’s disease

Wenbin Xu; Aocheng Ji; Lu Han; Hao Xiong; Yiyi Jin; Wen Lin; Yonghui Wu; Yun Wang; Huan Zhong; Longxin Xiong; Chunyan Zeng

doi:10.1371/journal.pone.0353031

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Open Access

Peer-reviewed

Research Article

From gut to pancreas: Shared genetic susceptibility and biological convergence in acute pancreatitis and Crohn’s disease

Wenbin Xu ,

Contributed equally to this work with: Wenbin Xu, Aocheng Ji, Lu Han

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft

Affiliations Department of Gastroenterology, Jiangxi Province Hospital of Integrated Chinese and Western Medicine (Central Hospital of Nanchang City), Nanchang, Jiangxi, China, Department of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China
⨯
Aocheng Ji ,

Contributed equally to this work with: Wenbin Xu, Aocheng Ji, Lu Han

Roles Data curation, Investigation, Visualization, Writing – original draft

Affiliations Department of Gastroenterology, Jiangxi Province Hospital of Integrated Chinese and Western Medicine (Central Hospital of Nanchang City), Nanchang, Jiangxi, China, Department of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China
⨯
Lu Han ,

Contributed equally to this work with: Wenbin Xu, Aocheng Ji, Lu Han

Roles Formal analysis, Investigation, Writing – original draft

Affiliations Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, Postdoctoral Innovation Practice Base, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China
⨯
Hao Xiong,

Roles Formal analysis, Methodology, Software

Affiliation Eye Hospital of China Academy of Chinese Medical Sciences, Beijing, China
⨯
Yiyi Jin,

Roles Data curation, Validation, Visualization

Affiliation Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China
⨯
Wen Lin,

Roles Data curation, Validation, Visualization

Affiliation Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China
⨯
Yonghui Wu,

Roles Data curation, Resources, Validation

Affiliation Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China
⨯
Yun Wang,

Roles Investigation, Software, Validation

Affiliation Department of Gastroenterology, Jiangxi Province Hospital of Integrated Chinese and Western Medicine (Central Hospital of Nanchang City), Nanchang, Jiangxi, China
⨯
Huan Zhong,

Roles Formal analysis, Methodology, Software

Affiliation Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Longxin Xiong ,

Roles Supervision, Writing – review & editing

* E-mail: zengchunyan2024@163.com (CZ); 2363915097@qq.com (LX)

Affiliation Department of General Surgery, Central Hospital of Nanchang City, Nanchang, Jiangxi, China
⨯
Chunyan Zeng

Roles Project administration, Supervision, Writing – review & editing

* E-mail: zengchunyan2024@163.com (CZ); 2363915097@qq.com (LX)

Affiliation Department of Gastroenterology, Jiangxi Province Hospital of Integrated Chinese and Western Medicine (Central Hospital of Nanchang City), Nanchang, Jiangxi, China

https://orcid.org/0000-0001-5018-0212

⨯

From gut to pancreas: Shared genetic susceptibility and biological convergence in acute pancreatitis and Crohn’s disease

Wenbin Xu,
Aocheng Ji,
Lu Han,
Hao Xiong,
Yiyi Jin,
Wen Lin,
Yonghui Wu,
Yun Wang,
Huan Zhong,
Longxin Xiong

Published: September 11, 2026
https://doi.org/10.1371/journal.pone.0353031

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