Pharmacokinetic model selection for infliximab based on inflammatory bowel disease phenotype and severity: Toward model-informed precision dosing

Ana Homšek Ilić; Marija Jovanović; Srđan Marković; Sandra Vezmar Kovačević; Tamara Knežević Ivanovski; Đorđe Kralj; Petar Svorcan; Katarina Vučićević

doi:10.1371/journal.pone.0352967

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Open Access

Peer-reviewed

Research Article

Pharmacokinetic model selection for infliximab based on inflammatory bowel disease phenotype and severity: Toward model-informed precision dosing

Ana Homšek Ilić,

Roles Data curation, Formal analysis, Investigation, Software, Visualization, Writing – original draft

Affiliation Department of Pharmacokinetics and Clinical Pharmacy, University of Belgrade - Faculty of Pharmacy, Belgrade, Republic of Serbia
⨯
Marija Jovanović,

Roles Investigation, Methodology, Software, Writing – original draft

Affiliation Department of Pharmacokinetics and Clinical Pharmacy, University of Belgrade - Faculty of Pharmacy, Belgrade, Republic of Serbia
⨯
Srđan Marković,

Roles Data curation, Investigation, Resources, Writing – review & editing

Affiliations University Hospital Medical Centre “Zvezdara”, Department of Gastroenterology and Hepatology, Belgrade, Republic of Serbia, University of Belgrade - Faculty of Medicine, Belgrade, Republic of Serbia
⨯
Sandra Vezmar Kovačević,

Roles Investigation, Validation, Writing – original draft

Affiliation Department of Pharmacokinetics and Clinical Pharmacy, University of Belgrade - Faculty of Pharmacy, Belgrade, Republic of Serbia
⨯
Tamara Knežević Ivanovski,

Roles Data curation, Investigation, Writing – review & editing

Affiliation University Hospital Medical Centre “Zvezdara”, Department of Gastroenterology and Hepatology, Belgrade, Republic of Serbia
⨯
Đorđe Kralj,

Roles Data curation, Investigation, Writing – review & editing

Affiliation University Hospital Medical Centre “Zvezdara”, Department of Gastroenterology and Hepatology, Belgrade, Republic of Serbia
⨯
Petar Svorcan,

Roles Data curation, Investigation, Writing – review & editing

Affiliations University Hospital Medical Centre “Zvezdara”, Department of Gastroenterology and Hepatology, Belgrade, Republic of Serbia, University of Belgrade - Faculty of Medicine, Belgrade, Republic of Serbia
⨯
Katarina Vučićević

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Validation, Writing – review & editing

* E-mail: katarina.vucicevic@pharmacy.bg.ac.rs

Affiliation Department of Pharmacokinetics and Clinical Pharmacy, University of Belgrade - Faculty of Pharmacy, Belgrade, Republic of Serbia

https://orcid.org/0000-0001-9676-5785

⨯

Pharmacokinetic model selection for infliximab based on inflammatory bowel disease phenotype and severity: Toward model-informed precision dosing

Ana Homšek Ilić,
Marija Jovanović,
Srđan Marković,
Sandra Vezmar Kovačević,
Tamara Knežević Ivanovski,
Đorđe Kralj,
Petar Svorcan,
Katarina Vučićević

Published: July 24, 2026
https://doi.org/10.1371/journal.pone.0352967

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Ulcerative colitis
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Inflammatory bowel disease
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Crohn's disease
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