Gene expression profiling of recipient immune cells induced by 7 × 19 CAR-T cell dosing in a syngeneic mouse model

Yo Muraki; Yuumi Okuzono; Rina Kurisu; Akiko Abiru; Yukimi Sakoda; Koji Tamada; Chihiro Take

doi:10.1371/journal.pone.0352813

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Open Access

Peer-reviewed

Research Article

Gene expression profiling of recipient immune cells induced by 7 × 19 CAR-T cell dosing in a syngeneic mouse model

Yo Muraki,

Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

Affiliation Oncology Drug Discovery Unit Japan, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

https://orcid.org/0000-0001-6891-3074

⨯
Yuumi Okuzono,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Oncology Drug Discovery Unit Japan, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

https://orcid.org/0000-0003-2438-5243

⨯
Rina Kurisu,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Oncology Drug Discovery Unit Japan, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Akiko Abiru,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Oncology Drug Discovery Unit Japan, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Yukimi Sakoda,

Roles Conceptualization, Investigation, Supervision, Writing – review & editing

Affiliations Noile-Immune Biotech Inc., Minato-ku, Tokyo, Japan, Research Institute for Cell Design Medical Science, Yamaguchi University, Ube City, Yamaguchi, Japan, Department of Immunology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
⨯
Koji Tamada,

Roles Conceptualization, Investigation, Supervision, Writing – review & editing

Affiliations Noile-Immune Biotech Inc., Minato-ku, Tokyo, Japan, Research Institute for Cell Design Medical Science, Yamaguchi University, Ube City, Yamaguchi, Japan, Department of Immunology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
⨯
Chihiro Take

Roles Conceptualization, Data curation, Investigation, Supervision, Validation, Writing – review & editing

* E-mail: chihiro.akimoto@takeda.com

Affiliation Oncology Drug Discovery Unit Japan, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

https://orcid.org/0009-0008-0103-5594

⨯

Gene expression profiling of recipient immune cells induced by 7 × 19 CAR-T cell dosing in a syngeneic mouse model

Yo Muraki,
Yuumi Okuzono,
Rina Kurisu,
Akiko Abiru,
Yukimi Sakoda,
Koji Tamada,
Chihiro Take

Published: July 17, 2026
https://doi.org/10.1371/journal.pone.0352813

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Cancers and neoplasms
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Immune cells
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Cancer treatment
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Gene expression
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Flow cytometry
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Transcriptome analysis
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Cytotoxic T cells
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