HIV-1 Nef inhibits the JAK/STAT signaling pathway by inducing proteasomal degradation of STAT1

• Roger L. Rodrigues ,

  Contributed equally to this work with: Roger L. Rodrigues, Mara E. da Silva-Januário

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Center for Virology Research and Department of Cell and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

  ⨯
• Mara E. da Silva-Januário ,

  Contributed equally to this work with: Roger L. Rodrigues, Mara E. da Silva-Januário

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Center for Virology Research and Department of Cell and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

  ⨯
• Vinicius B. Apolloni,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Virology Research and Department of Cell and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

  https://orcid.org/0000-0001-7405-611X

  ⨯
• Constanza E. Espada,

  Roles Investigation, Writing – review & editing

  Affiliation Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Center of Biological Sciences, Federal University of Santa Catarina, Santa Catarina, Brazil

  ⨯
• Taissa R. Jorge,

  Roles Investigation, Writing – review & editing

  Affiliation Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Center of Biological Sciences, Federal University of Santa Catarina, Santa Catarina, Brazil

  ⨯
• Lucas A. Tavares,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Virology Research and Department of Cell and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

  https://orcid.org/0000-0001-7883-1443

  ⨯
• Andreia N. de Carvalho,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Virology Research and Department of Cell and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

  ⨯
• Juliano P. Souza,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Virology Research and Department of Cell and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

  ⨯
• Eurico Arruda,

  Roles Formal analysis, Supervision, Writing – review & editing

  Affiliation Center for Virology Research and Department of Cell and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

  ⨯
• Iranaia Assunção-Miranda,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Department of Virology, Paulo de Góes Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

  ⨯
• Daniel S. Mansur,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Center of Biological Sciences, Federal University of Santa Catarina, Santa Catarina, Brazil

  ⨯
• Luis L. P. daSilva

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: lldasilva@fmrp.usp.br

  Affiliation Center for Virology Research and Department of Cell and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

  https://orcid.org/0000-0003-3558-0087

  ⨯