Pachymic acid alleviates circadian rhythm disorders in high-fat diet-induced obesity mice via the sphingolipid pathway

Hong Yang; Yingxiu Mei; Jilan Chen; Jiawei Chen; Jiushuang Zhu; Lu Zhang; Yanju Gong; Gan Luo; Weijun Ding

doi:10.1371/journal.pone.0352604

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Open Access

Peer-reviewed

Research Article

Pachymic acid alleviates circadian rhythm disorders in high-fat diet-induced obesity mice via the sphingolipid pathway

Hong Yang,

Roles Data curation, Funding acquisition, Writing – original draft

Affiliation School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China

https://orcid.org/0000-0002-5145-4243

⨯
Yingxiu Mei,

Roles Data curation, Formal analysis

Affiliation School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China
⨯
Jilan Chen,

Roles Conceptualization, Formal analysis

Affiliation School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China
⨯
Jiawei Chen,

Roles Investigation

Affiliation School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China
⨯
Jiushuang Zhu,

Roles Methodology

Affiliation School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China
⨯
Lu Zhang,

Roles Validation, Visualization

Affiliation School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China
⨯
Yanju Gong,

Roles Software, Validation

Affiliation School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China
⨯
Gan Luo ,

Contributed equally to this work with: Gan Luo, Weijun Ding

Roles Data curation, Funding acquisition

* E-mail: luoganhd@126.com (GL); Dingweijun@cdutcm.edu.cn (WJD)

Affiliation Department of Orthopedics, Chengdu Integrated Traditional Chinese Medicine & Western Medicine Hospital/Chengdu First People’s Hospital, Chengdu, China
⨯
Weijun Ding

Contributed equally to this work with: Gan Luo, Weijun Ding

Roles Project administration, Writing – review & editing

* E-mail: luoganhd@126.com (GL); Dingweijun@cdutcm.edu.cn (WJD)

Affiliation School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China

https://orcid.org/0000-0002-4933-7347

⨯

Pachymic acid alleviates circadian rhythm disorders in high-fat diet-induced obesity mice via the sphingolipid pathway

Hong Yang,
Yingxiu Mei,
Jilan Chen,
Jiawei Chen,
Jiushuang Zhu,
Lu Zhang,
Yanju Gong,
Gan Luo,
Weijun Ding

Published: July 1, 2026
https://doi.org/10.1371/journal.pone.0352604

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Circadian rhythms
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Obesity
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