Engineering of episomal plasmid structure to enhance non-viral Poly(beta-amino ester) nanoparticle gene delivery to liver and brain cancer cells

• Joanna Yang,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Translational ImmunoEngineering Center, Translational Therapeutics and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0003-0455-0635

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• Jack Kollings,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliations Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Translational ImmunoEngineering Center, Translational Therapeutics and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Ethan Idnani,

  Roles Investigation

  Affiliations Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Translational ImmunoEngineering Center, Translational Therapeutics and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• David R. Wilson,

  Roles Conceptualization, Investigation, Methodology

  Affiliations Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Translational ImmunoEngineering Center, Translational Therapeutics and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Isabella G. Cozzone,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliations Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Translational ImmunoEngineering Center, Translational Therapeutics and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Shanelle Mendes,

  Roles Investigation

  Affiliations Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Translational ImmunoEngineering Center, Translational Therapeutics and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Mahita Varanasi,

  Roles Investigation

  Affiliations Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Translational ImmunoEngineering Center, Translational Therapeutics and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Stephany Y. Tzeng ,

  Roles Supervision, Writing – review & editing, Funding acquisition

  ^* green@jhu.edu (JJG), stzeng1@jhmi.edu (SYT)

  Affiliations Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Translational ImmunoEngineering Center, Translational Therapeutics and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Jordan J. Green

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  ^* green@jhu.edu (JJG), stzeng1@jhmi.edu (SYT)

  Affiliations Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Translational ImmunoEngineering Center, Translational Therapeutics and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America, Institute for NanoBioTechnology and the Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, Maryland, United States of America

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