Mitochondrial oxidative stress promotes the accumulation of advanced glycation end products

Firoz Akhter; Sourav Samanta; Alexandre A. Sosunov; Huawei Wu; Ethan Kim Tieu; Shi Fang Yan; Shirley ShiDu Yan

doi:10.1371/journal.pone.0352355

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Open Access

Peer-reviewed

Research Article

Mitochondrial oxidative stress promotes the accumulation of advanced glycation end products

Firoz Akhter ,

Contributed equally to this work with: Firoz Akhter, Sourav Samanta

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Division of Surgical Science of Department of Surgery, Columbia University in New York, New York, United States of America
⨯
Sourav Samanta ,

Contributed equally to this work with: Firoz Akhter, Sourav Samanta

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Division of Surgical Science of Department of Surgery, Columbia University in New York, New York, United States of America
⨯
Alexandre A. Sosunov,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Division of Surgical Science of Department of Surgery, Columbia University in New York, New York, United States of America
⨯
Huawei Wu,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Division of Surgical Science of Department of Surgery, Columbia University in New York, New York, United States of America
⨯
Ethan Kim Tieu,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization

Affiliation Division of Surgical Science of Department of Surgery, Columbia University in New York, New York, United States of America
⨯
Shi Fang Yan ,

Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: sdy1@cumc.columbia.edu or sy18@cumc.columbia.edu

Affiliation Division of Surgical Science of Department of Surgery, Columbia University in New York, New York, United States of America

https://orcid.org/0000-0002-2597-8967

⨯
Shirley ShiDu Yan

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: sdy1@cumc.columbia.edu or sy18@cumc.columbia.edu

Affiliation Division of Surgical Science of Department of Surgery, Columbia University in New York, New York, United States of America
⨯

Mitochondrial oxidative stress promotes the accumulation of advanced glycation end products

Firoz Akhter,
Sourav Samanta,
Alexandre A. Sosunov,
Huawei Wu,
Ethan Kim Tieu,
Shi Fang Yan,
Shirley ShiDu Yan

Published: June 23, 2026
https://doi.org/10.1371/journal.pone.0352355

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