A novel m7G RNA methylation-related signature associated with MAPK signaling pathways in acute ischemic stroke

Wei-Gang Gong; Jian-Wei Lou; Sen Yin; Fang-Pu Yu; Wei Wu

doi:10.1371/journal.pone.0352280

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Open Access

Peer-reviewed

Research Article

A novel m7G RNA methylation-related signature associated with MAPK signaling pathways in acute ischemic stroke

Wei-Gang Gong,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
⨯
Jian-Wei Lou ,

Roles Data curation, Investigation, Methodology, Software, Validation

* E-mail: yufp0211@126.com (FPY); loujianwei@qiluhospital.com (JWL); wuwei710825@126.com (WW)

Affiliation Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
⨯
Sen Yin,

Roles Data curation, Investigation, Resources, Supervision, Validation, Visualization

Affiliation Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
⨯
Fang-Pu Yu ,

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources, Software, Visualization, Writing – original draft, Writing – review & editing

* E-mail: yufp0211@126.com (FPY); loujianwei@qiluhospital.com (JWL); wuwei710825@126.com (WW)

Affiliation The Key Laboratory of Cardiovascular Remodeling & Function Research, Chinese Ministry of Education, Chinese Ministry of Health & Chinese Academy of Medical Sciences, & The State & Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
⨯
Wei Wu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Resources, Validation, Writing – review & editing

* E-mail: yufp0211@126.com (FPY); loujianwei@qiluhospital.com (JWL); wuwei710825@126.com (WW)

Affiliation Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China

https://orcid.org/0009-0006-2411-635X

⨯

A novel m7G RNA methylation-related signature associated with MAPK signaling pathways in acute ischemic stroke

Wei-Gang Gong,
Jian-Wei Lou,
Sen Yin,
Fang-Pu Yu,
Wei Wu

Published: June 23, 2026
https://doi.org/10.1371/journal.pone.0352280

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Methylation
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Ischemic stroke
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DNA methylation
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Messenger RNA
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RNA sequencing
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Sequence motif analysis
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MAPK signaling cascades
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Gene expression
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