Integrated NEK7-inflammasome and platelet transcriptomic signature generates mechanistic hypotheses in heart failure

• Zelan Wu ,

  Contributed equally to this work with: Zelan Wu, Zhisheng Zheng

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft

  Affiliations Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, Guizhou Medical University, Guiyang, Guizhou, China

  https://orcid.org/0009-0004-3254-6144

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• Zhisheng Zheng ,

  Contributed equally to this work with: Zelan Wu, Zhisheng Zheng

  Roles Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliations Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, Guizhou Medical University, Guiyang, Guizhou, China

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• Yongkang Li,

  Roles Investigation, Software, Visualization

  Affiliations Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, Guizhou Medical University, Guiyang, Guizhou, China

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• Botao Li,

  Roles Validation, Visualization

  Affiliations Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, Guizhou Medical University, Guiyang, Guizhou, China

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• Shiyu Pi,

  Roles Data curation, Software

  Affiliations Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, Guizhou Medical University, Guiyang, Guizhou, China

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• Daiqin Wu,

  Roles Data curation, Funding acquisition, Validation

  Affiliations Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, Guizhou Medical University, Guiyang, Guizhou, China

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• Zhangrong Chen,

  Roles Resources

  Affiliations Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, Guizhou Medical University, Guiyang, Guizhou, China

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• Xia Li,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation Guizhou Precision Medicine Institute, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China

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• Wei Li ,

  Roles Resources, Writing – review & editing

  * E-mail: fjdai2011@foxmail.com; liwei249188@sina.com

  Affiliations Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, Guizhou Medical University, Guiyang, Guizhou, China

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• Fangjie Dai

  Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: fjdai2011@foxmail.com; liwei249188@sina.com

  Affiliations Department of Cardiovascular Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, The Key Laboratory of Myocardial Remodeling Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, Guizhou Medical University, Guiyang, Guizhou, China

  https://orcid.org/0000-0003-2652-9423

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