Omipalisib reduces hyperphosphorylated tau protein by modulating mTOR-autophagy pathway

• Haeun Hwang ,

  Roles Conceptualization, Investigation, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliation Department of Fundamental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea

  ⨯
• Namkwon Kim ,

  Roles Conceptualization, Formal analysis, Writing – original draft

  ¶‡ These authors share first authorship on this work.

  Affiliations Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea, Department of Neurology, Yale School of Medicine, New Haven, Connecticut, United States of America

  ⨯
• Subyn Jeon,

  Roles Formal analysis, Investigation

  Affiliation Department of Fundamental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea

  ⨯
• Yoojin Lee,

  Roles Formal analysis, Investigation

  Affiliation Department of Fundamental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea

  ⨯
• Jeongmin Son,

  Roles Formal analysis, Investigation

  Affiliation Department of Fundamental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea

  ⨯
• Seung Ho Jeon,

  Roles Formal analysis, Methodology

  Affiliation Department of Fundamental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea

  ⨯
• Yeongae Lee,

  Roles Formal analysis, Methodology

  Affiliation Department of Fundamental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea

  ⨯
• Min Sung Gee,

  Roles Formal analysis, Methodology

  Affiliation Department of Neurobiology and Behavior, University of California, Irvine, California, United States of America

  ⨯
• Kyung-Soo Inn ,

  Roles Supervision, Writing – review & editing

  * E-mail: innks@khu.ac.kr (KSI); jklee3984@khu.ac.kr (JKL)

  Affiliations Department of Fundamental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea, College of Pharmacy and Institute of Integrated Pharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea

  ⨯
• Jong Kil Lee

  Roles Funding acquisition, Supervision, Writing – review & editing

  * E-mail: innks@khu.ac.kr (KSI); jklee3984@khu.ac.kr (JKL)

  Affiliations Department of Fundamental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea, College of Pharmacy and Institute of Integrated Pharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea

  https://orcid.org/0000-0002-2428-3530

  ⨯