HIF-2α drives osteoarthritis progression via suppression of the HDAC4-ATF4-CHOP signaling axis

• Pinpin Jiang ,

  Roles Validation, Visualization, Writing – original draft

  ¶☯ These authors contributed equally to this work and share first authorship.

  Affiliation Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, China

  https://orcid.org/0000-0001-5680-0742

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• Hang Wang ,

  Roles Validation, Visualization, Writing – original draft

  ¶☯ These authors contributed equally to this work and share first authorship.

  Affiliation Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, China

  ⨯
• Yujia Li,

  Roles Methodology, Writing – review & editing

  Affiliations Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, China, Academy of Medical Sciences, Shanxi Medical University, Taiyuan, China

  ⨯
• Yuanyu Zhang,

  Roles Formal analysis, Investigation, Resources

  Affiliation Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, China

  ⨯
• Jingrui Huang,

  Roles Investigation, Resources, Software

  Affiliation Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, China

  ⨯
• Yukun Xu,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, China

  ⨯
• Dahai Rong,

  Roles Validation, Visualization

  Affiliation Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, China

  ⨯
• Danni Ruan,

  Roles Investigation, Methodology

  Affiliations Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, China, Academy of Medical Sciences, Shanxi Medical University, Taiyuan, China

  ⨯
• Yao Wang,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliations Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, China, Academy of Medical Sciences, Shanxi Medical University, Taiyuan, China

  ⨯
• Jie Yuan,

  Roles Conceptualization, Methodology

  Affiliation Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, China

  ⨯
• Pengcui Li

  Roles Conceptualization, Project administration, Supervision

  * E-mail: lpc1977@163.com

  Affiliation Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, China

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