IRX3 depletion promotes early cardiac commitment of hiPSC-Derived Cardiomyocytes

• Agatha Ribeiro Kalthof ,

  Contributed equally to this work with: Agatha Ribeiro Kalthof, Nikolas Dresch Ferreira

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

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• Nikolas Dresch Ferreira ,

  Contributed equally to this work with: Agatha Ribeiro Kalthof, Nikolas Dresch Ferreira

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

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• Caio Mateus Silva,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

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• Iuri Cordeiro Valadão,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  Affiliation Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

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• Iguaracy Pinheiro de Sousa,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliations Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, United Kingdom

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• Ester Riserio Matos Bertoldi,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

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• Vanessa Morais Lima,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

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• Lauro Thiago Turaca,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

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• Ana Beatriz Ruiz Afonso Barbosa,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

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• Miriam Helena Fonseca-Alaniz,

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

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• Jean-Paul Concordet,

  Roles Resources

  Affiliation Laboratoire Structure et Instabilité des Génomes, Inserm U1154, CNRS UMR7196, Muséum National d’Histoire Naturelle, Paris, France

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• Elida Adalgisa Neri,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

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• Jose E. Krieger

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: j.krieger@hc.fm.usp.br

  Affiliation Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

  https://orcid.org/0000-0001-5464-1792

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