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Open Access

Peer-reviewed

Research Article

Screening disease feature genes and analyzing correlations with immune cell infiltration in knee osteoarthritis chondrocytes based on multiple machine learning algorithms

Jing-le Zhuge,

Roles Conceptualization

Affiliation Department of Orthopaedics, Wenzhou TCM Hospital Of Zhejiang Chinese Medical University, Wenzhou, P.R. China
⨯
Xi-yong Li,

Roles Data curation

Affiliation Department of Orthopaedics, Wenzhou TCM Hospital Of Zhejiang Chinese Medical University, Wenzhou, P.R. China
⨯
Yong-le Wang,

Roles Writing – original draft

Affiliation Department of Orthopaedics, Wenzhou TCM Hospital Of Zhejiang Chinese Medical University, Wenzhou, P.R. China
⨯
Juan-fen Ma

Roles Conceptualization, Writing – original draft

* E-mail: juanfenma@163.com

Affiliation Department of Orthopaedics, Wenzhou TCM Hospital Of Zhejiang Chinese Medical University, Wenzhou, P.R. China

https://orcid.org/0009-0007-8023-6716

⨯

Screening disease feature genes and analyzing correlations with immune cell infiltration in knee osteoarthritis chondrocytes based on multiple machine learning algorithms

Jing-le Zhuge,
Xi-yong Li,
Yong-le Wang,
Juan-fen Ma

x

Published: June 16, 2026
https://doi.org/10.1371/journal.pone.0351666

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Immune cells
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Gene expression
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Chondrocytes
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Osteoarthritis
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Machine learning algorithms
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Inflammation
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Macrophages
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Cartilage
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