Bioinformatic identification of CD8+ T cell activation mediated by key genes in fecal microbiota transplantation for irritable bowel syndrome

Ying Fei; Ming-Yi Gao; Nan Qiao; Jia Hu; Ling He; Jiao-Li Zhou; Ning-Ning Zheng; Ting-Ting Liu

doi:10.1371/journal.pone.0351574

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Open Access

Peer-reviewed

Research Article

Bioinformatic identification of CD8+ T cell activation mediated by key genes in fecal microbiota transplantation for irritable bowel syndrome

Ying Fei ,

Contributed equally to this work with: Ying Fei, Ming-Yi Gao

Roles Conceptualization

Affiliation Department of Gastroenterology, YingTan Chinese Medicine Hospital, Yingtan, Jiangxi, China
⨯
Ming-Yi Gao ,

Contributed equally to this work with: Ying Fei, Ming-Yi Gao

Roles Writing – original draft

Affiliation Graduate College, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China
⨯
Nan Qiao,

Roles Visualization

Affiliation Department of Student Affairs, Jiangxi Flight University, Nanchang, Jiangxi, China
⨯
Jia Hu ,

Roles Writing – review & editing

* E-mail: hujia2@jxutcm.edu.cn (JH), heling118@126.com (LH).

Affiliations Department of Gastroenterology, YingTan Chinese Medicine Hospital, Yingtan, Jiangxi, China, Department of Gastroenterology, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China

https://orcid.org/0000-0003-2387-1557

⨯
Ling He ,

Roles Writing – review & editing

* E-mail: hujia2@jxutcm.edu.cn (JH), heling118@126.com (LH).

Affiliation Department of Gastroenterology, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China
⨯
Jiao-Li Zhou,

Roles Data curation

Affiliation Graduate College, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China
⨯
Ning-Ning Zheng,

Roles Data curation

Affiliation Graduate College, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China
⨯
Ting-Ting Liu

Roles Data curation

Affiliation Graduate College, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China
⨯

Bioinformatic identification of CD8+ T cell activation mediated by key genes in fecal microbiota transplantation for irritable bowel syndrome

Ying Fei,
Ming-Yi Gao,
Nan Qiao,
Jia Hu,
Ling He,
Jiao-Li Zhou,
Ning-Ning Zheng,
Ting-Ting Liu

Published: June 16, 2026
https://doi.org/10.1371/journal.pone.0351574

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Cytotoxic T cells
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Cell activation
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Gene expression
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Irritable bowel syndrome
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Colon
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Gene regulation
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Transcriptome analysis
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