Identification of candidate sex hormone-associated genes and immune infiltration characteristics in osteoarthritis based on bioinformatics analysis and machine learning

Yishu Wang; Ling Zhu; Shuna Jin; Yuhan Wang; Zhaoxiang Zeng; Yunzhou Zuo; Xingliang Xiang; Xugui Li; Rongzeng Huang; Chengwu Song

doi:10.1371/journal.pone.0351556

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Open Access

Peer-reviewed

Research Article

Identification of candidate sex hormone-associated genes and immune infiltration characteristics in osteoarthritis based on bioinformatics analysis and machine learning

Yishu Wang ,

Contributed equally to this work with: Yishu Wang, Ling Zhu

Roles Conceptualization, Data curation, Investigation, Software, Validation, Writing – original draft

Affiliation School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China
⨯
Ling Zhu ,

Contributed equally to this work with: Yishu Wang, Ling Zhu

Roles Data curation, Resources

Affiliation The Affiliated Hospital of Wuhan Sports University, Wuhan, China
⨯
Shuna Jin,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing – review & editing

Affiliations School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, China, Hubei Shizhen Laboratory, Wuhan, China
⨯
Yuhan Wang,

Roles Investigation, Software, Validation

Affiliation School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China
⨯
Zhaoxiang Zeng,

Roles Investigation, Software, Validation

Affiliation School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China
⨯
Yunzhou Zuo,

Roles Data curation, Funding acquisition, Resources

Affiliation The Affiliated Hospital of Wuhan Sports University, Wuhan, China
⨯
Xingliang Xiang,

Roles Investigation, Resources, Supervision

Affiliation The Affiliated Hospital of Wuhan Sports University, Wuhan, China
⨯
Xugui Li ,

Roles Data curation, Resources

* E-mail: lixugui2000@163.com (XL); rongzenghuang_2018@hbucm.edu.cn (RH); chengwusong_2016@hbucm.edu.cn (CS)

Affiliations The Affiliated Hospital of Wuhan Sports University, Wuhan, China, School of Acupuncture-Moxibustion and Orthopedics, Hubei University of Chinese Medicine, Wuhan, China
⨯
Rongzeng Huang ,

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

* E-mail: lixugui2000@163.com (XL); rongzenghuang_2018@hbucm.edu.cn (RH); chengwusong_2016@hbucm.edu.cn (CS)

Affiliation School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China
⨯
Chengwu Song

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

* E-mail: lixugui2000@163.com (XL); rongzenghuang_2018@hbucm.edu.cn (RH); chengwusong_2016@hbucm.edu.cn (CS)

Affiliations School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China, Hubei Shizhen Laboratory, Wuhan, China

https://orcid.org/0000-0002-4429-0500

⨯

Identification of candidate sex hormone-associated genes and immune infiltration characteristics in osteoarthritis based on bioinformatics analysis and machine learning

Yishu Wang,
Ling Zhu,
Shuna Jin,
Yuhan Wang,
Zhaoxiang Zeng,
Yunzhou Zuo,
Xingliang Xiang,
Xugui Li,
Rongzeng Huang,
Chengwu Song

Published: June 12, 2026
https://doi.org/10.1371/journal.pone.0351556

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Sex hormones
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Osteoarthritis
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Gene expression
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Extracellular matrix
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