Lactiplantibacillus plantarum GUANKE alleviates Zearalenone-induced intestinal dysfunction by modulating oxidative stress and inflammation

Qiaoning Chang; Yanchao Zhao; Han Li; Bin Zhang; Meidi Zhang; Pei Zhao; Jingmin He; Bugao Li; Ming D. Li

doi:10.1371/journal.pone.0351300

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Open Access

Peer-reviewed

Research Article

Lactiplantibacillus plantarum GUANKE alleviates Zearalenone-induced intestinal dysfunction by modulating oxidative stress and inflammation

Qiaoning Chang,

Roles Investigation, Methodology, Validation, Writing – original draft

Affiliations College of Animal Sciences, Shanxi Agricultural University, Taigu, Shanxi, China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⨯
Yanchao Zhao,

Roles Methodology

Affiliations College of Animal Sciences, Shanxi Agricultural University, Taigu, Shanxi, China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⨯
Han Li,

Roles Methodology

Affiliations College of Animal Sciences, Shanxi Agricultural University, Taigu, Shanxi, China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⨯
Bin Zhang,

Roles Conceptualization, Formal analysis, Methodology, Writing – original draft

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⨯
Meidi Zhang,

Roles Formal analysis, Methodology

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⨯
Pei Zhao,

Roles Methodology

Affiliations State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, College of Biological Sciences, Shanxi Agricultural University, Taigu, Shanxi, China
⨯
Jingmin He,

Roles Formal analysis, Methodology

Affiliations State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, College of Biological Sciences, Shanxi Agricultural University, Taigu, Shanxi, China
⨯
Bugao Li ,

Roles Writing – review & editing

* E-mail: ml2km@zju.edu.cn (MDL); jinrenn@163.com (BL)

Affiliation College of Animal Sciences, Shanxi Agricultural University, Taigu, Shanxi, China
⨯
Ming D. Li

Roles Funding acquisition, Writing – review & editing

* E-mail: ml2km@zju.edu.cn (MDL); jinrenn@163.com (BL)

Affiliations State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, College of Biological Sciences, Shanxi Agricultural University, Taigu, Shanxi, China

https://orcid.org/0000-0002-6873-9472

⨯

Lactiplantibacillus plantarum GUANKE alleviates Zearalenone-induced intestinal dysfunction by modulating oxidative stress and inflammation

Qiaoning Chang,
Yanchao Zhao,
Han Li,
Bin Zhang,
Meidi Zhang,
Pei Zhao,
Jingmin He,
Bugao Li,
Ming D. Li

Published: July 1, 2026
https://doi.org/10.1371/journal.pone.0351300

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