Higher frequency of subclonal anti-EGFR resistance mutations in post-treatment samples from patients with colorectal cancer liver metastases following anti-EGFR-based conversion chemotherapy

• Christoph Steup ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  * E-mail: steup@med.uni-frankfurt.de

  Affiliation Goethe University Frankfurt, University Hospital Frankfurt, Department of Internal Medicine, Frankfurt am Main, Germany

  https://orcid.org/0000-0001-6991-9910

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• Antonia Mondorf,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Goethe University Frankfurt, University Hospital Frankfurt, Department of Internal Medicine, Frankfurt am Main, Germany

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• Peter Wild,

  Roles Funding acquisition, Methodology, Project administration, Resources, Software, Supervision, Writing – review & editing

  Affiliation Goethe University Frankfurt, Dr. Senckenberg Institutes of Pathology and Human Genetics, University Hospital Frankfurt, Frankfurt am Main, Germany

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• Ursula Pession,

  Roles Data curation, Project administration, Writing – review & editing

  Affiliation Goethe University Frankfurt, University Hospital Frankfurt, Department of General, Visceral, Transplant and Thoracic Surgery, Frankfurt am Main, Germany

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• Wolf Otto Bechstein,

  Roles Data curation, Project administration, Supervision, Writing – review & editing

  Affiliation Goethe University Frankfurt, University Hospital Frankfurt, Department of General, Visceral, Transplant and Thoracic Surgery, Frankfurt am Main, Germany

  https://orcid.org/0000-0002-3267-8145

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• Florian A. Michael,

  Roles Data curation, Validation, Writing – review & editing

  Affiliation Goethe University Frankfurt, University Hospital Frankfurt, Department of Internal Medicine, Frankfurt am Main, Germany

  https://orcid.org/0000-0002-9305-3691

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• Melanie Winter,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Goethe University Frankfurt, Dr. Senckenberg Institutes of Pathology and Human Genetics, University Hospital Frankfurt, Frankfurt am Main, Germany

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• Julia Bein,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Goethe University Frankfurt, Dr. Senckenberg Institutes of Pathology and Human Genetics, University Hospital Frankfurt, Frankfurt am Main, Germany

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• Stefan Zeuzem,

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Writing – review & editing

  Affiliation Goethe University Frankfurt, University Hospital Frankfurt, Department of Internal Medicine, Frankfurt am Main, Germany

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• Jörg Trojan,

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  Affiliation Goethe University Frankfurt, University Hospital Frankfurt, Department of Internal Medicine, Frankfurt am Main, Germany

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• Christine Koch

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Goethe University Frankfurt, University Hospital Frankfurt, Department of Internal Medicine, Frankfurt am Main, Germany

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