Trial Files: Leveraging large language models to summarize practice-changing clinical trials for clinicians

• Katarina Zorcic ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: katarina.zorcic@gmail.com

  ¶☯ Katarina Zorcic and Emily Bartsch are co-first authors.

  Affiliations Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, School of Medicine, Queen’s University, Faculty of Health Sciences, Kingston, Ontario, Canada

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• Emily Bartsch ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶☯ Katarina Zorcic and Emily Bartsch are co-first authors.

  Affiliation Division of Internal Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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• Bryant Lim,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

  Affiliation Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada

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• Genevieve McCallum,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

  Affiliation Department of Anesthesiology, Pharmacology, and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

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• Tamara Van Bakel,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

  Affiliation Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada

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• Alison Hacker,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

  Affiliation School of Medicine, Queen’s University, Faculty of Health Sciences, Kingston, Ontario, Canada

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• Michael Fralick

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶† Deceased February 1, 2026.

  Affiliations Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, Division of Internal Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

  https://orcid.org/0000-0002-2082-2445

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