Effectiveness and implementation of a primary healthcare intervention for multimorbidity and frailty among urban older adults in India: Protocol for the Multi-FrAME cluster randomized trial

Jaya Singh Kshatri; Haimanti Bhattacharya; Siddhartha Goutam; Ashok Kumar Mahakuda; Rasmiranjan Nayak; Kavitha Adukkadukam Kambikanam; Tanveer Rehman; Abhinav Sinha; Mamata Manjari Sahu; Kshanaprava Mohakud; Purna Chandra Das; Sanghamitra Pati

doi:10.1371/journal.pone.0351110

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Effectiveness and implementation of a primary healthcare intervention for multimorbidity and frailty among urban older adults in India: Protocol for the Multi-FrAME cluster randomized trial

Jaya Singh Kshatri ,

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Conceptualization

* E-mail: kshatri.js@icmr.gov.in, jayasingh.kshatri@maastrichtuniversity.nl

Affiliations ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India, Maastricht University, The Netherlands

https://orcid.org/0000-0003-3616-3402

⨯
Haimanti Bhattacharya,

Roles Data curation, Methodology, Project administration, Software, Supervision, Validation, Writing – original draft

Affiliation ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India
⨯
Siddhartha Goutam,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources

Affiliation IMS and SUM Hospital-II, Phulnakhra, Bhubaneswar, India
⨯
Ashok Kumar Mahakuda,

Roles Methodology, Project administration, Software, Supervision, Writing – review & editing

Affiliation ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India
⨯
Rasmiranjan Nayak,

Roles Methodology, Project administration, Software, Supervision, Writing – review & editing

Affiliation ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India
⨯
Kavitha Adukkadukam Kambikanam,

Roles Data curation, Methodology, Project administration, Software, Supervision, Validation, Writing – original draft

Affiliation ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India
⨯
Tanveer Rehman,

Roles Data curation, Formal analysis, Investigation, Project administration

Affiliation ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India
⨯
Abhinav Sinha,

Roles Conceptualization, Methodology

Affiliation ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India
⨯
Mamata Manjari Sahu,

Roles Methodology, Resources, Supervision

Affiliation Swami Vivekanand National Institute of Rehabilitation Training and Research (SVNIRTAR), Cuttack, India
⨯
Kshanaprava Mohakud,

Roles Methodology, Resources

Affiliation Swami Vivekanand National Institute of Rehabilitation Training and Research (SVNIRTAR), Cuttack, India
⨯
Purna Chandra Das,

Roles Investigation, Methodology, Supervision

Affiliation SUM Ultimate Medicare Hospital, Bhubaneswar, India
⨯
Sanghamitra Pati

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

Affiliations ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India, Indian Council of Medical Research Centre, (Department of Health Research, Ministry of Health and Family Welfare, Government of India), New Delhi, India
⨯

Effectiveness and implementation of a primary healthcare intervention for multimorbidity and frailty among urban older adults in India: Protocol for the Multi-FrAME cluster randomized trial

Jaya Singh Kshatri,
Haimanti Bhattacharya,
Siddhartha Goutam,
Ashok Kumar Mahakuda,
Rasmiranjan Nayak,
Kavitha Adukkadukam Kambikanam,
Tanveer Rehman,
Abhinav Sinha,
Mamata Manjari Sahu,
Kshanaprava Mohakud

Published: June 18, 2026
https://doi.org/10.1371/journal.pone.0351110

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