The mTOR/Akt pathway is involved in regulating astrocyte growth and GLT-1 expression during cerebral ischemia-reperfusion

Qiuling Li; Yiwen Yu; Huan Deng; Biao Li; Hao Zhao; Dong Lei; Mi Li; Shansha Xie; Jingmei Yu; Yuping Zhao; Shubin Yin; YiFei Ji

doi:10.1371/journal.pone.0351107

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Open Access

Peer-reviewed

Research Article

The mTOR/Akt pathway is involved in regulating astrocyte growth and GLT-1 expression during cerebral ischemia-reperfusion

Qiuling Li,

Roles Writing – original draft, Writing – review & editing

Affiliations Department of Neurology, Second Clinical College, North Sichuan Medical College, Nanchong, China, Department of Neurology, Nanning First People’s Hospital, Nanning, China
⨯
Yiwen Yu,

Roles Investigation, Writing – original draft

Affiliation Department of Neurology, Second Clinical College, North Sichuan Medical College, Nanchong, China
⨯
Huan Deng,

Roles Data curation

Affiliation Department of Neurology, Second Clinical College, North Sichuan Medical College, Nanchong, China
⨯
Biao Li,

Roles Software

Affiliation Department of Neurology, Second Clinical College, North Sichuan Medical College, Nanchong, China
⨯
Hao Zhao,

Roles Methodology

Affiliation Department of Neurology, Second Clinical College, North Sichuan Medical College, Nanchong, China
⨯
Dong Lei,

Roles Software

Affiliation Department of Neurology, Second Clinical College, North Sichuan Medical College, Nanchong, China
⨯
Mi Li,

Roles Supervision

Affiliation Department of Neurology, Yilong County People’s Hospital, Nanchong, China
⨯
Shansha Xie,

Roles Data curation

Affiliations Department of Neurology, Second Clinical College, North Sichuan Medical College, Nanchong, China, Department of Neurology, Ya ‘an People’s Hospital, Ya ‘an, China
⨯
Jingmei Yu,

Roles Supervision

Affiliation Department of Neurology, Second Clinical College, North Sichuan Medical College, Nanchong, China
⨯
Yuping Zhao,

Roles Validation

Affiliation Department of Neurology, Second Clinical College, North Sichuan Medical College, Nanchong, China
⨯
Shubin Yin,

Roles Supervision

Affiliation Department of Neurology, Second Clinical College, North Sichuan Medical College, Nanchong, China
⨯
YiFei Ji

Roles Writing – review & editing

* E-mail: jiyifei_2003@163.com

Affiliation Department of Neurology, Second Clinical College, North Sichuan Medical College, Nanchong, China

https://orcid.org/0000-0001-9518-0486

⨯

The mTOR/Akt pathway is involved in regulating astrocyte growth and GLT-1 expression during cerebral ischemia-reperfusion

Qiuling Li,
Yiwen Yu,
Huan Deng,
Biao Li,
Hao Zhao,
Dong Lei,
Mi Li,
Shansha Xie,
Jingmei Yu,
Yuping Zhao

Published: June 12, 2026
https://doi.org/10.1371/journal.pone.0351107

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Astrocytes
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Brain damage
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Apoptosis
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Cerebral ischemia
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Neurons
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Quantitative analysis
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AKT signaling cascade
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Ischemic stroke
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