Immunomodulatory effects of a multi-component pharmacological intervention on diabetic peripheral neuropathy in type 2 diabetic rats: An exploratory study

Lu Zhang; Si Wang; Jie Lei; Lingrui Zeng; Ailin Lu; Yongqing Wu; Yuan Shi; Jing Yang; Mengrui Yuan; Hongyi Liu

doi:10.1371/journal.pone.0350984

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Open Access

Peer-reviewed

Research Article

Immunomodulatory effects of a multi-component pharmacological intervention on diabetic peripheral neuropathy in type 2 diabetic rats: An exploratory study

Lu Zhang ,

Roles Conceptualization, Data curation, Writing – original draft, Writing – review & editing

¶☯ These authors have contributed equally to this work and share first authorship.

Affiliation Cancer Precision Medicine Center, Tianjin Cancer Hospital Airport Hospital, Tianjin, China

https://orcid.org/0000-0002-2074-8687

⨯
Si Wang ,

Roles Conceptualization, Data curation

¶☯ These authors have contributed equally to this work and share first authorship.

Affiliation The Second Clinical Medical College, Yunnan University of Traditional Chinese Medicine, Yunnan, China
⨯
Jie Lei ,

Roles Conceptualization, Data curation

¶☯ These authors have contributed equally to this work and share first authorship.

Affiliation The First Clinical Medical College, Yunnan University of Traditional Chinese Medicine, Yunnan, China
⨯
Lingrui Zeng,

Roles Methodology

Affiliation Cancer Precision Medicine Center, Tianjin Cancer Hospital Airport Hospital, Tianjin, China
⨯
Ailin Lu,

Roles Software

Affiliation The First Clinical Medical College, Yunnan University of Traditional Chinese Medicine, Yunnan, China
⨯
Yongqing Wu,

Roles Formal analysis

Affiliation The First Clinical Medical College, Yunnan University of Traditional Chinese Medicine, Yunnan, China
⨯
Yuan Shi,

Roles Validation

Affiliation The First Clinical Medical College, Yunnan University of Traditional Chinese Medicine, Yunnan, China
⨯
Jing Yang,

Roles Methodology

Affiliation The First Clinical Medical College, Yunnan University of Traditional Chinese Medicine, Yunnan, China
⨯
Mengrui Yuan,

Roles Software

Affiliation The First Clinical Medical College, Yunnan University of Traditional Chinese Medicine, Yunnan, China
⨯
Hongyi Liu

Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

* E-mail: realliuhongyi@126.com

Affiliation Scientific Research Department, Yunnan Provincial Hospital of Traditional Chinese Medicine, Yunnan, China
⨯

Immunomodulatory effects of a multi-component pharmacological intervention on diabetic peripheral neuropathy in type 2 diabetic rats: An exploratory study

Lu Zhang,
Si Wang,
Jie Lei,
Lingrui Zeng,
Ailin Lu,
Yongqing Wu,
Yuan Shi,
Jing Yang,
Mengrui Yuan,
Hongyi Liu

Published: June 4, 2026
https://doi.org/10.1371/journal.pone.0350984

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Type 2 diabetes
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