Topical medium-length PDRN enhances dermal extracellular matrix repair in photodamaged skin via PI3K–Akt/TGF-β–regulated pathways

• Rui Ye,

  Roles Conceptualization, Data curation, Formal analysis, Writing – original draft

  Affiliations Department of Dermatology & Venereology, Center of Cosmetic Safety and Efficacy Evaluation and NMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics, West China Hospital, Sichuan University, Chengdu, China, UNISKIN Research Institute on Skin Aging, Inertia Shanghai Biotechnology Co., Ltd., Shanghai, China, DermaHealth Shanghai Biotechnology Co., Ltd., Shanghai, China

  ⨯
• Qianqian Wang,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China

  ⨯
• Le Du,

  Roles Resources, Supervision, Validation

  Affiliations UNISKIN Research Institute on Skin Aging, Inertia Shanghai Biotechnology Co., Ltd., Shanghai, China, DermaHealth Shanghai Biotechnology Co., Ltd., Shanghai, China

  ⨯
• Li Li ,

  Roles Project administration, Supervision, Validation

  * E-mail: lilihx_scu@scu.edu.cn (LL); hufan@uniskin.com (FH)

  Affiliation Department of Dermatology & Venereology, Center of Cosmetic Safety and Efficacy Evaluation and NMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics, West China Hospital, Sichuan University, Chengdu, China

  ⨯
• Fan Hu

  Roles Conceptualization, Investigation, Supervision, Writing – original draft, Writing – review & editing, Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: lilihx_scu@scu.edu.cn (LL); hufan@uniskin.com (FH)

  Affiliations UNISKIN Research Institute on Skin Aging, Inertia Shanghai Biotechnology Co., Ltd., Shanghai, China, DermaHealth Shanghai Biotechnology Co., Ltd., Shanghai, China

  https://orcid.org/0009-0006-5227-7142

  ⨯