Molecular characterization of superficial zone chondrocytes under pro-inflammatory and biomechanical stress conditions

Fengrui Liu; Xueting Ding; Pengcui Li; Jie Yuan; Li Guo; Sen Zhao; Gaige Wu; Xiaochun Wei

doi:10.1371/journal.pone.0350746

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Open Access

Peer-reviewed

Research Article

Molecular characterization of superficial zone chondrocytes under pro-inflammatory and biomechanical stress conditions

Fengrui Liu,

Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft

Affiliations Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
⨯
Xueting Ding,

Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

Affiliations Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China, Department of Embryology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, China
⨯
Pengcui Li,

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliations Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China, Department of Embryology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, China
⨯
Jie Yuan,

Roles Data curation, Resources, Supervision, Validation

Affiliation Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
⨯
Li Guo,

Roles Funding acquisition, Methodology, Supervision, Writing – review & editing

Affiliation Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
⨯
Sen Zhao,

Roles Data curation, Resources, Validation, Visualization

Affiliation Taiyuan Microscopic Hand Surgery Hospital, Taiyuan, Shanxi, China
⨯
Gaige Wu ,

Roles Data curation, Formal analysis, Investigation, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: sdeygksys@163.com

Affiliation Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
⨯
Xiaochun Wei

Roles Data curation, Funding acquisition, Supervision, Writing – review & editing

* E-mail: sdeygksys@163.com

Affiliation Key Laboratory of Bone and Soft Tissue Injury, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China

https://orcid.org/0000-0002-6175-4346

⨯

Molecular characterization of superficial zone chondrocytes under pro-inflammatory and biomechanical stress conditions

Fengrui Liu,
Xueting Ding,
Pengcui Li,
Jie Yuan,
Li Guo,
Sen Zhao,
Gaige Wu,
Xiaochun Wei

Published: June 12, 2026
https://doi.org/10.1371/journal.pone.0350746

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Inflammation
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Chondrocytes
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Apoptosis
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Gene expression
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Osteoarthritis
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Cartilage
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Flow cytometry
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Articular cartilage
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