Integrating network toxicology, machine learning, and single-cell sequencing to reveal the FASN-mediated role of phenolic endocrine disruptors in water in promoting prostate cancer

Xinyao Zhu; Qilong Wu; Yuqi Li; Zhiyu Liu; Yang Zeng; Zhiqiang Zeng; Yubo Zhou; Lunhong Zou; Xiaochun Wu; Dan Zhao; Qingfu Deng; Tao Zhou

doi:10.1371/journal.pone.0350638

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Open Access

Peer-reviewed

Research Article

Integrating network toxicology, machine learning, and single-cell sequencing to reveal the FASN-mediated role of phenolic endocrine disruptors in water in promoting prostate cancer

Xinyao Zhu,

Roles Conceptualization, Data curation, Writing – original draft, Writing – review & editing

Affiliations Department of Urology, Santai Hospital Affiliated to North Sichuan Medical College, Mianyang, Sichuan, China, Department of Urology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
⨯
Qilong Wu,

Roles Formal analysis, Investigation

Affiliation Department of Urology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
⨯
Yuqi Li,

Roles Methodology, Project administration

Affiliation Department of Urology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
⨯
Zhiyu Liu,

Roles Methodology, Project administration

Affiliation Department of Urology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
⨯
Yang Zeng,

Roles Methodology, Project administration

Affiliation Department of Urology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
⨯
Zhiqiang Zeng,

Roles Resources, Software

Affiliation Department of Urology, Santai Hospital Affiliated to North Sichuan Medical College, Mianyang, Sichuan, China
⨯
Yubo Zhou,

Roles Software, Supervision

Affiliation Department of Urology, Santai Hospital Affiliated to North Sichuan Medical College, Mianyang, Sichuan, China
⨯
Lunhong Zou,

Roles Supervision, Validation

Affiliation Department of Urology, Santai Hospital Affiliated to North Sichuan Medical College, Mianyang, Sichuan, China
⨯
Xiaochun Wu,

Roles Validation, Visualization

Affiliation Department of Nursing, Santai Hospital Affiliated to North Sichuan Medical College, Mianyang, Sichuan, China
⨯
Dan Zhao ,

Roles Visualization, Writing – review & editing

* E-mail: zddyx2025@163.com (DZ); dengqingfu@swmu.edu.cn (QD); mnztdoc@163.com (TZ)

Affiliation Department of Nursing, Santai Hospital Affiliated to North Sichuan Medical College, Mianyang, Sichuan, China
⨯
Qingfu Deng ,

Roles Funding acquisition, Writing – original draft, Writing – review & editing

* E-mail: zddyx2025@163.com (DZ); dengqingfu@swmu.edu.cn (QD); mnztdoc@163.com (TZ)

Affiliation Department of Urology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China

https://orcid.org/0009-0008-4836-9495

⨯
Tao Zhou

Roles Software, Writing – review & editing

* E-mail: zddyx2025@163.com (DZ); dengqingfu@swmu.edu.cn (QD); mnztdoc@163.com (TZ)

Affiliations Department of Urology, Santai Hospital Affiliated to North Sichuan Medical College, Mianyang, Sichuan, China, Department of Urology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
⨯

Integrating network toxicology, machine learning, and single-cell sequencing to reveal the FASN-mediated role of phenolic endocrine disruptors in water in promoting prostate cancer

Xinyao Zhu,
Qilong Wu,
Yuqi Li,
Zhiyu Liu,
Yang Zeng,
Zhiqiang Zeng,
Yubo Zhou,
Lunhong Zou,
Xiaochun Wu,
Dan Zhao

Published: June 2, 2026
https://doi.org/10.1371/journal.pone.0350638

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