Pharmacokinetic interactions between three SGLT2 inhibitors and telmisartan: A focus on empagliflozin, ertugliflozin, and henagliflozin

Xin Zhou; Yanru Deng; Caihui Guo; Ying Li; Yuhao Fu; Zhi Wang; Zhanjun Dong

doi:10.1371/journal.pone.0350400

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Open Access

Peer-reviewed

Research Article

Pharmacokinetic interactions between three SGLT2 inhibitors and telmisartan: A focus on empagliflozin, ertugliflozin, and henagliflozin

Xin Zhou,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft

Affiliations Graduate School, Hebei Medical University, Shijiazhuang, China, Hebei General Hospital, Hebei Key Laboratory of Clinical Pharmacy, Shijiazhuang, China
⨯
Yanru Deng,

Roles Data curation, Investigation, Methodology, Software

Affiliation Hebei General Hospital, Hebei Key Laboratory of Clinical Pharmacy, Shijiazhuang, China
⨯
Caihui Guo,

Roles Investigation, Methodology, Resources, Software

Affiliation Hebei General Hospital, Hebei Key Laboratory of Clinical Pharmacy, Shijiazhuang, China
⨯
Ying Li,

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliation Hebei General Hospital, Hebei Key Laboratory of Clinical Pharmacy, Shijiazhuang, China
⨯
Yuhao Fu,

Roles Data curation, Investigation, Software

Affiliation Department of Pharmacy, Hebei Chest Hospital, Shijiazhuang, China
⨯
Zhi Wang,

Roles Data curation, Investigation, Software

Affiliations Graduate School, Hebei Medical University, Shijiazhuang, China, Hebei General Hospital, Hebei Key Laboratory of Clinical Pharmacy, Shijiazhuang, China
⨯
Zhanjun Dong

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

* E-mail: dzjhbgh@126.com

Affiliations Graduate School, Hebei Medical University, Shijiazhuang, China, Hebei General Hospital, Hebei Key Laboratory of Clinical Pharmacy, Shijiazhuang, China

https://orcid.org/0000-0001-5349-4970

⨯

Pharmacokinetic interactions between three SGLT2 inhibitors and telmisartan: A focus on empagliflozin, ertugliflozin, and henagliflozin

Xin Zhou,
Yanru Deng,
Caihui Guo,
Ying Li,
Yuhao Fu,
Zhi Wang,
Zhanjun Dong

Published: June 22, 2026
https://doi.org/10.1371/journal.pone.0350400

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