Lipid droplet associated protein HILPDA promotes hypoxia-induced ferroptosis by driving LPCAT3-mediated polyunsaturated phospholipids enrichment

Zhenmei Song; Wenli Li; Jie Zeng; Xuexin Wang; Dezhi Wang; Xingchen Liao

doi:10.1371/journal.pone.0350129

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Open Access

Peer-reviewed

Research Article

Lipid droplet associated protein HILPDA promotes hypoxia-induced ferroptosis by driving LPCAT3-mediated polyunsaturated phospholipids enrichment

Zhenmei Song ,

Roles Methodology, Visualization

* E-mail: songzhenmei@163.com (ZS); wangxuexin98@163.com (XW); zilv_wang@126.com (DW); lxingchen95@163.com (XL)

Affiliation Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, China
⨯
Wenli Li,

Roles Methodology

Affiliation Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China
⨯
Jie Zeng,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliation Department of Urology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China
⨯
Xuexin Wang ,

Roles Methodology, Visualization

* E-mail: songzhenmei@163.com (ZS); wangxuexin98@163.com (XW); zilv_wang@126.com (DW); lxingchen95@163.com (XL)

Affiliations Medical School of Chinese PLA, Chinese PLA General Hospital, Beijing, China, Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China
⨯
Dezhi Wang ,

Roles Conceptualization, Visualization, Methodology, Writing – original draft, Writing – review & editing

* E-mail: songzhenmei@163.com (ZS); wangxuexin98@163.com (XW); zilv_wang@126.com (DW); lxingchen95@163.com (XL)

Affiliations Medical School of Chinese PLA, Chinese PLA General Hospital, Beijing, China, Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China
⨯
Xingchen Liao

Roles Conceptualization, Methodology, Visualization, Writing – original draft, Writing – review & editing

* E-mail: songzhenmei@163.com (ZS); wangxuexin98@163.com (XW); zilv_wang@126.com (DW); lxingchen95@163.com (XL)

Affiliations Medical School of Chinese PLA, Chinese PLA General Hospital, Beijing, China, Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China

https://orcid.org/0009-0006-3254-2631

⨯

Lipid droplet associated protein HILPDA promotes hypoxia-induced ferroptosis by driving LPCAT3-mediated polyunsaturated phospholipids enrichment

Zhenmei Song,
Wenli Li,
Jie Zeng,
Xuexin Wang,
Dezhi Wang,
Xingchen Liao

Published: June 8, 2026
https://doi.org/10.1371/journal.pone.0350129

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Hypoxia
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Cell death
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Lipid peroxidation
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Cell staining
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Mitochondria
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Lipid metabolism
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Plasmid construction
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Transfection
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