A bioactive hydrogel integrating bFGF/VEGFA gene-loaded nanoparticles and platelet-rich plasma for accelerated full-thickness skin wound healing

Yan Duan; Weixin Wang; Yuanyuan Jin; Ming Jiang; Bolin Wang; Jianle Chen; Yun Jiang

doi:10.1371/journal.pone.0350087

Loading metrics

Open Access

Peer-reviewed

Research Article

A bioactive hydrogel integrating bFGF/VEGFA gene-loaded nanoparticles and platelet-rich plasma for accelerated full-thickness skin wound healing

Yan Duan ,

Contributed equally to this work with: Yan Duan, Weixin Wang, Yuanyuan Jin, Bolin Wang, Jianle Chen, Yun Jiang

Roles Data curation, Formal analysis, Validation, Writing – original draft

Affiliation Department of Burn and Plastic Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China
⨯
Weixin Wang ,

Contributed equally to this work with: Yan Duan, Weixin Wang, Yuanyuan Jin, Bolin Wang, Jianle Chen, Yun Jiang

Roles Data curation, Formal analysis, Investigation, Validation

Affiliation Department of Thoracic Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China
⨯
Yuanyuan Jin ,

Contributed equally to this work with: Yan Duan, Weixin Wang, Yuanyuan Jin, Bolin Wang, Jianle Chen, Yun Jiang

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Burn and Plastic Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China
⨯
Ming Jiang,

Roles Data curation, Investigation

Affiliation Department of Burn and Plastic Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China
⨯
Bolin Wang ,

Contributed equally to this work with: Yan Duan, Weixin Wang, Yuanyuan Jin, Bolin Wang, Jianle Chen, Yun Jiang

Roles Investigation, Supervision, Validation

* E-mail: 942811549@qq.com (YJ); jsshcjl@163.com (JLC); bolin980218@163.com (BLW)

Affiliation Department of Burn and Plastic Surgery, The First People’s Hospital of Kunshan, Suzhou, Jiangsu, China
⨯
Jianle Chen ,

Contributed equally to this work with: Yan Duan, Weixin Wang, Yuanyuan Jin, Bolin Wang, Jianle Chen, Yun Jiang

Roles Supervision, Validation, Writing – review & editing

* E-mail: 942811549@qq.com (YJ); jsshcjl@163.com (JLC); bolin980218@163.com (BLW)

Affiliation Department of Thoracic Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China
⨯
Yun Jiang

Contributed equally to this work with: Yan Duan, Weixin Wang, Yuanyuan Jin, Bolin Wang, Jianle Chen, Yun Jiang

Roles Supervision, Validation, Writing – review & editing

* E-mail: 942811549@qq.com (YJ); jsshcjl@163.com (JLC); bolin980218@163.com (BLW)

Affiliation Department of Burn and Plastic Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China

https://orcid.org/0000-0003-3233-0859

⨯

A bioactive hydrogel integrating bFGF/VEGFA gene-loaded nanoparticles and platelet-rich plasma for accelerated full-thickness skin wound healing

Yan Duan,
Weixin Wang,
Yuanyuan Jin,
Ming Jiang,
Bolin Wang,
Jianle Chen,
Yun Jiang

Published: May 26, 2026
https://doi.org/10.1371/journal.pone.0350087

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Wound healing
Is the Subject Area "Wound healing" applicable to this article?

Thanks for your feedback.
Gels
Is the Subject Area "Gels" applicable to this article?

Thanks for your feedback.
Collagens
Is the Subject Area "Collagens" applicable to this article?

Thanks for your feedback.
Nanoparticles
Is the Subject Area "Nanoparticles" applicable to this article?

Thanks for your feedback.
Growth factors
Is the Subject Area "Growth factors" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Platelets
Is the Subject Area "Platelets" applicable to this article?

Thanks for your feedback.
Angiogenesis
Is the Subject Area "Angiogenesis" applicable to this article?

Thanks for your feedback.