The inhibitors of miR-224-5p, miR-339-5p, and miR-1198-5p improve auditory function by promoting the expression of neuritin in hearing loss mice

Pingping Meng; Zhiwei Zhong; Yin Song; Yu Wei; Jiawei Sun; Jingyi Chen; Yunhua Zhang; Jingling Zhu

doi:10.1371/journal.pone.0349821

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Open Access

Peer-reviewed

Research Article

The inhibitors of miR-224-5p, miR-339-5p, and miR-1198-5p improve auditory function by promoting the expression of neuritin in hearing loss mice

Pingping Meng ,

Contributed equally to this work with: Pingping Meng, Zhiwei Zhong, Yin Song

Roles Methodology, Writing – original draft

Affiliation Department of Biochemistry, The Key Laboratory of Xinjiang Endemic & Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China
⨯
Zhiwei Zhong ,

Contributed equally to this work with: Pingping Meng, Zhiwei Zhong, Yin Song

Roles Methodology, Validation

Affiliation Department of Biochemistry, The Key Laboratory of Xinjiang Endemic & Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China
⨯
Yin Song ,

Contributed equally to this work with: Pingping Meng, Zhiwei Zhong, Yin Song

Roles Conceptualization, Methodology

Affiliation Jiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang, China
⨯
Yu Wei,

Roles Validation

Affiliation First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, Xinjiang, China
⨯
Jiawei Sun,

Roles Validation

Affiliation Department of Biochemistry, The Key Laboratory of Xinjiang Endemic & Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China
⨯
Jingyi Chen,

Roles Validation

Affiliation Department of Biochemistry, The Key Laboratory of Xinjiang Endemic & Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China
⨯
Yunhua Zhang ,

Roles Writing – review & editing

* E-mail: yunhuazhang@shzu.edu.cn (YZ); azhujinglinga@126.com (JZ)

Affiliation Department of Biochemistry, The Key Laboratory of Xinjiang Endemic & Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China
⨯
Jingling Zhu

Roles Writing – review & editing

* E-mail: yunhuazhang@shzu.edu.cn (YZ); azhujinglinga@126.com (JZ)

Affiliation Department of Biochemistry, The Key Laboratory of Xinjiang Endemic & Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China

https://orcid.org/0000-0003-3667-6347

⨯

The inhibitors of miR-224-5p, miR-339-5p, and miR-1198-5p improve auditory function by promoting the expression of neuritin in hearing loss mice

Pingping Meng,
Zhiwei Zhong,
Yin Song,
Yu Wei,
Jiawei Sun,
Jingyi Chen,
Yunhua Zhang,
Jingling Zhu

Published: May 21, 2026
https://doi.org/10.1371/journal.pone.0349821

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