Prevalence of multiple morbidities and cancers in individuals with Down syndrome: A matched descriptive study using linked electronic health record data

• Caoimhe McKenna ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Visualization, Writing – original draft, Writing – review & editing

  ¶☯ These authors contributed equally to this work and should be considered joint first authors.

  Affiliations Great Ormond Street Institute of Child Health, University College London, London, United Kingdom, NI Regional Molecular Diagnostics Service, Belfast Health and Social Care Trust, Belfast, United Kingdom, Queen’s University Belfast, Belfast, United Kingdom

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• Kabir Yoshinori Khanna ,

  Roles Formal analysis, Project administration, Supervision, Visualization, Writing – review & editing

  ¶☯ These authors contributed equally to this work and should be considered joint first authors.

  Affiliations Frimley Health NHS Foundation Trust, Frimley, United Kingdom, Aceso Global Health Consultants Pte Limited, Singapore, Singapore

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• Meghan A. Cupp ,

  Roles Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliation CAUSALab, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

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• Darlington David Faijue ,

  Roles Supervision, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliations Aceso Global Health Consultants Pte Limited, Singapore, Singapore, Institute for Infection and Immunity, City St George’s University of London, London, United Kingdom

  https://orcid.org/0000-0001-7138-1531

  ⨯
• Anne G.M. Schilder ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization

  ¶‡ These authors also contributed equally to this work.

  Affiliation evidENT, UCL Ear Institute and NIHR UCLH Biomedical Research Centre, London, United Kingdom

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• Arturo Gonzalez-Izquierdo ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliations Institute of Health Informatics, University College London, London, United Kingdom, Health Data Research UK, London, United Kingdom, Centre for Health Data Science, Department of Applied Health Research, University of Birmingham, Birmingham, United Kingdom, National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom

  https://orcid.org/0000-0002-0984-5830

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• Muhammad Qummer ul Arfeen ,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – original draft

  ¶‡ These authors also contributed equally to this work.

  Affiliation Institute of Health Informatics, University College London, London, United Kingdom

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• Andre Strydom ,

  Roles Conceptualization, Methodology, Project administration, Supervision, Validation, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliation Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom

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• Dougal Hargreaves ,

  Roles Conceptualization, Methodology, Supervision

  ¶‡ These authors also contributed equally to this work.

  Affiliation School of Public Health, Imperial College London, London, United Kingdom

  ⨯
• Rachel Xue Ning Lee ,

  Roles Methodology, Resources

  ¶‡ These authors also contributed equally to this work.

  Affiliation Royal Derby Hospital, University Hospital of Derby and Burton NHS Foundation Trust, United Kingdom

  ⨯
• Monica Lakhanpaul ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation

  ¶‡ These authors also contributed equally to this work.

  Affiliations Great Ormond Street Institute of Child Health, University College London, London, United Kingdom, Nottingham University NHS Trust, Nottingham, United Kingdom

  https://orcid.org/0000-0002-9855-2043

  ⨯
• Logan Manikam

  Roles Conceptualization, Methodology, Project administration, Resources, Supervision, Validation

  * E-mail: logan.manikam.10@ucl.ac.uk

  Current address: Department of Epidemiology and Public Health, University College London, London, United Kingdom

  ¶‡ These authors also contributed equally to this work.

  Affiliations Aceso Global Health Consultants Pte Limited, Singapore, Singapore, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, United Kingdom, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China

  https://orcid.org/0000-0001-5288-3325

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