A data-driven framework for modeling the dendritic spine continuum using dimensionality reduction and clustering toward understanding synaptic plasticity

• Uma Shashi Sharma ,

  Contributed equally to this work with: Uma Shashi Sharma, Philip R. LeDuc, Yongjie Jessica Zhang

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  * E-mail: umas@andrew.cmu.edu

  Affiliation Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0009-0000-5551-8091

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• Philip R. LeDuc ,

  Contributed equally to this work with: Uma Shashi Sharma, Philip R. LeDuc, Yongjie Jessica Zhang

  Roles Conceptualization, Project administration, Resources, Validation, Writing – review & editing

  Affiliation Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

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• Yongjie Jessica Zhang

  Contributed equally to this work with: Uma Shashi Sharma, Philip R. LeDuc, Yongjie Jessica Zhang

  Roles Project administration, Resources, Validation, Writing – review & editing

  Affiliation Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0001-7436-9757

  ⨯