Characterizing malignant prognostic signatures in primary glioma based on single-cell and bulk transcriptome sequencing

Yuhui Gong; Haoran Guo; Haolong Ding; Xiaolong Hu; Zhiliang Ding; Mian Ma; Junjie Chen

doi:10.1371/journal.pone.0349749

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Open Access

Peer-reviewed

Research Article

Characterizing malignant prognostic signatures in primary glioma based on single-cell and bulk transcriptome sequencing

Yuhui Gong ,

Contributed equally to this work with: Yuhui Gong, Haoran Guo

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

Affiliation Department of Neurosurgery, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu Province, China
⨯
Haoran Guo ,

Contributed equally to this work with: Yuhui Gong, Haoran Guo

Roles Data curation, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft

Affiliation Central Laboratory, The Affiliate Suqian Hospital of Xuzhou Medical University, Suqian, Jiangsu Province, China
⨯
Haolong Ding,

Roles Data curation, Investigation, Resources

Affiliation Department of Neurosurgery, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu Province, China
⨯
Xiaolong Hu,

Roles Data curation, Formal analysis, Resources

Affiliation Department of Neurosurgery, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu Province, China
⨯
Zhiliang Ding,

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation Department of Neurosurgery, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu Province, China
⨯
Mian Ma ,

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: 343739595@qq.com (MM); cjjsuzhou2024@163.com (JC)

Affiliation Department of Neurosurgery, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu Province, China
⨯
Junjie Chen

Roles Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: 343739595@qq.com (MM); cjjsuzhou2024@163.com (JC)

Affiliation Department of General Surgery, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China

https://orcid.org/0009-0003-7885-5463

⨯

Characterizing malignant prognostic signatures in primary glioma based on single-cell and bulk transcriptome sequencing

Yuhui Gong,
Haoran Guo,
Haolong Ding,
Xiaolong Hu,
Zhiliang Ding,
Mian Ma,
Junjie Chen

Published: June 5, 2026
https://doi.org/10.1371/journal.pone.0349749

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