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Open Access
Peer-reviewed
Research Article
Machine learning reveals microbiome differences by periodontitis severity
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Soo Hyun Seo ,
Contributed equally to this work with: Soo Hyun Seo, Jae Won Lee
Roles Formal analysis, Investigation, Validation, Writing – original draft
Affiliations Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea, Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Department of Genomic Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
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Jae Won Lee ,
Contributed equally to this work with: Soo Hyun Seo, Jae Won Lee
Roles Formal analysis, Validation, Visualization, Writing – original draft
Affiliation Accugene Inc., Incheon, Republic of Korea
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Sujin Oh,
Roles Data curation, Writing – review & editing
Affiliation Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
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Jin-Sil Hong,
Roles Data curation, Writing – review & editing
Affiliation Department of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
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Ban Seok Lee,
Roles Formal analysis, Writing – review & editing
Affiliation Accugene Inc., Incheon, Republic of Korea
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Sun Jae Kwon,
Roles Formal analysis, Writing – review & editing
Affiliation Accugene Inc., Incheon, Republic of Korea
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Keun-Suh Kim,
Roles Data curation, Formal analysis, Writing – review & editing
Affiliation Department of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
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Jung Soo Park,
Roles Data curation, Writing – review & editing
Affiliation Department of Periodontology, Korea University Anam Hospital, Seoul, Republic of Korea
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Ju Sun Heo,
Roles Data curation, Writing – review & editing
Affiliations Department of Pediatrics, Seoul National University Children’s Hospital, Seoul, Republic of Korea, Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea
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Ki Hoon Ahn,
Roles Data curation, Writing – review & editing
Affiliation Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Republic of Korea
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Hyo‐Jung Lee ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Supervision, Writing – review & editing
* E-mail: periolee@gmail.com (H-JL); m91w95pf@snu.ac.kr (KUP)
Affiliations Department of Genomic Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea, Department of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
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Kyoung Un Park
Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing
* E-mail: periolee@gmail.com (H-JL); m91w95pf@snu.ac.kr (KUP)
Affiliations Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea, Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
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Machine learning reveals microbiome differences by periodontitis severity
- Soo Hyun Seo,
- Jae Won Lee,
- Sujin Oh,
- Jin-Sil Hong,
- Ban Seok Lee,
- Sun Jae Kwon,
- Keun-Suh Kim,
- Jung Soo Park,
- Ju Sun Heo,
- Ki Hoon Ahn
- Published: May 21, 2026
- https://doi.org/10.1371/journal.pone.0349686