Identifying and validating ITGB2 and HNRNPAB as diagnostic biomarkers in chronic obstructive pulmonary disease using bioinformatics and Integrated Machine Learning Methods

• Fengjun Zhang ,

  Contributed equally to this work with: Fengjun Zhang, Hui Li

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft

  Affiliation Department of Pulmonary Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

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• Hui Li ,

  Contributed equally to this work with: Fengjun Zhang, Hui Li

  Roles Conceptualization, Methodology, Visualization, Writing – original draft

  Affiliation School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China

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• Fan Wu,

  Roles Data curation

  Affiliation Department of Pulmonary Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

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• Dexian Xian,

  Roles Data curation

  Affiliation The First Clinical Medical, Shandong University of Chinese Medicine, Jinan, China

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• Feng Chen,

  Roles Software

  Affiliation Department of Integrated Chinese and Western Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China

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• Wenchang Xu,

  Roles Investigation

  Affiliation The First Clinical Medical, Shandong University of Chinese Medicine, Jinan, China

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• Yuchen He,

  Roles Resources

  Affiliation Department of rehabilitation, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

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• Xiaodan Liu ,

  Roles Project administration, Validation, Writing – review & editing

  * E-mail: zhangw1190@sina.com (WZ); hzhp403@126.com (XL)

  ¶‡ WZ and XL also contributed equally to this work.

  Affiliation School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China

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• Wei Zhang

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: zhangw1190@sina.com (WZ); hzhp403@126.com (XL)

  ¶‡ WZ and XL also contributed equally to this work.

  Affiliations Department of Pulmonary Diseases, Shuguang Hospital, Shanghai Institute of Infectious Diseases and Biosecurity, Shanghai University of Traditional Chinese Medicine, Shanghai, China, Zhang Wei Baoshan famous traditional Chinese medicine inheritance studio, Shanghai Baoshan Hospital of Integrated Chinese and Western Medicine, Shanghai, China, Institute of Infectious Diseases, Shanghai Institute of Traditional Chinese Medicine, Shanghai, China

  https://orcid.org/0000-0003-4816-8390

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