Multi-omics profiling reveals epidermal growth factor as a potential biomarker and therapeutic target in lupus nephritis and ANCA-associated vasculitis with rapidly progressive glomerulonephritis

• Mengli Xu ,

  Contributed equally to this work with: Mengli Xu, Qi Cheng, Yifan Xie

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft

  Affiliation Department of Nephrology, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China

  ⨯
• Qi Cheng ,

  Contributed equally to this work with: Mengli Xu, Qi Cheng, Yifan Xie

  Roles Conceptualization, Investigation, Methodology, Writing – original draft

  Affiliation Department of Rheumatology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

  ⨯
• Yifan Xie ,

  Contributed equally to this work with: Mengli Xu, Qi Cheng, Yifan Xie

  Roles Conceptualization, Data curation, Formal analysis, Methodology

  Affiliation Department of Rheumatology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

  ⨯
• Xin Chen,

  Roles Data curation, Investigation, Methodology

  Affiliation Department of Rheumatology, Jinhua Municipal Central Hospital, Jinhua, China

  ⨯
• Lingjiang Zhu,

  Roles Data curation, Methodology

  Affiliation Department of Rheumatology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

  ⨯
• Wenjing Su,

  Roles Data curation, Methodology

  Affiliation Department of Nephrology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China‌‌

  ⨯
• Yan Du ,

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: duyan2014@zju.edu.cn (YD); wuhx8855@zju.edu.cn (HW); Lukedaq@126.com (KL)

  Affiliation Department of Rheumatology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

  https://orcid.org/0000-0001-9931-4197

  ⨯
• Huaxiang Wu ,

  Roles Funding acquisition, Project administration, Writing – review & editing

  * E-mail: duyan2014@zju.edu.cn (YD); wuhx8855@zju.edu.cn (HW); Lukedaq@126.com (KL)

  Affiliation Department of Rheumatology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

  ⨯
• Keda Lu

  Roles Funding acquisition, Project administration, Writing – review & editing

  * E-mail: duyan2014@zju.edu.cn (YD); wuhx8855@zju.edu.cn (HW); Lukedaq@126.com (KL)

  Affiliation Department of Nephrology, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China

  ⨯