Integration of single-cell and bulk RNA sequencing reveals programmed cell death-associated transcriptional programs in sepsis-induced acute lung injury

Xin Li; Weihong Liu; Yucui Zhang; Guohan Xiang; Qianyu Bi; Xin Lin; Yang Liu; Tejin Ba; Li Kong; Yang Liu; Hao Hao

doi:10.1371/journal.pone.0349288

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Open Access

Peer-reviewed

Research Article

Integration of single-cell and bulk RNA sequencing reveals programmed cell death-associated transcriptional programs in sepsis-induced acute lung injury

Xin Li ,

Contributed equally to this work with: Xin Li, Weihong Liu

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliation Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China
⨯
Weihong Liu ,

Contributed equally to this work with: Xin Li, Weihong Liu

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliation Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China
⨯
Yucui Zhang,

Roles Data curation, Formal analysis, Software, Visualization, Writing – review & editing

Affiliation Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China
⨯
Guohan Xiang,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China
⨯
Qianyu Bi,

Roles Investigation, Methodology, Validation, Writing – review & editing

Affiliation Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China
⨯
Xin Lin,

Roles Investigation, Validation, Writing – review & editing

Affiliation Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China
⨯
Yang Liu,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing – review & editing

Affiliation Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China
⨯
Tejin Ba,

Roles Resources, Writing – review & editing

Affiliation Inner Mongolia Autonomous Region International Mongolian Medical Hospital, Hohhot, China
⨯
Li Kong,

Roles Resources, Writing – review & editing

Affiliation Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China
⨯
Yang Liu ,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: liuyang19920825@sina.com (YL); 71000311@sdutcm.edu.cn (HH)

Affiliation Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China
⨯
Hao Hao

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: liuyang19920825@sina.com (YL); 71000311@sdutcm.edu.cn (HH)

Affiliation Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China

https://orcid.org/0000-0003-4488-4840

⨯

Integration of single-cell and bulk RNA sequencing reveals programmed cell death-associated transcriptional programs in sepsis-induced acute lung injury

Xin Li,
Weihong Liu,
Yucui Zhang,
Guohan Xiang,
Qianyu Bi,
Xin Lin,
Yang Liu,
Tejin Ba,
Li Kong,
Yang Liu

Published: June 3, 2026
https://doi.org/10.1371/journal.pone.0349288

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