Identification of CAND1 as a DNA-dependent protein kinase-regulated coactivator of androgen receptor and the ARv7 splice variant

Ross A. Hamilton; Basil Paul; Ping Yi; Kimal Rajapakshe; Anil K. Panigrahi; Sandra L. Grimm; Cristian Coarfa; Anna Malovannaya; Nancy L. Weigel; David M. Lonard; Charles E. Foulds

doi:10.1371/journal.pone.0349130

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Open Access

Peer-reviewed

Research Article

Identification of CAND1 as a DNA-dependent protein kinase-regulated coactivator of androgen receptor and the ARv7 splice variant

Ross A. Hamilton,

Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America

https://orcid.org/0000-0002-8289-7522

⨯
Basil Paul,

Roles Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America

https://orcid.org/0000-0002-5046-9021

⨯
Ping Yi,

Roles Funding acquisition, Resources, Writing – review & editing

Affiliations Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, United States of America

https://orcid.org/0000-0001-9433-6805

⨯
Kimal Rajapakshe,

Roles Formal analysis, Visualization, Writing – review & editing

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Anil K. Panigrahi,

Roles Formal analysis, Investigation, Resources, Writing – review & editing

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Sandra L. Grimm,

Roles Formal analysis, Visualization, Writing – review & editing

Affiliations Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Cristian Coarfa,

Roles Formal analysis, Funding acquisition, Visualization, Writing – review & editing

Affiliations Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Anna Malovannaya,

Roles Formal analysis, Funding acquisition, Visualization, Writing – review & editing

Affiliations Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Biochemistry and Molecular Pharmacology,‌‌ Baylor College of Medicine, Houston, Texas, United States of America, Mass Spectrometry Proteomics Core, Advanced Technology Cores, ‌‌Baylor College of Medicine, Houston, Texas, United States of America
⨯
Nancy L. Weigel,

Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliations Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America
⨯
David M. Lonard ,

Roles Formal analysis, Funding acquisition, Writing – review & editing

* E-mail: dlonard@bcm.edu (DML); foulds@bcm.edu (CEF)

Affiliations Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Charles E. Foulds

Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: dlonard@bcm.edu (DML); foulds@bcm.edu (CEF)

Affiliations Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America, Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Medicine, Baylor College of Medicine,‌‌ Houston, Texas, United States of America
⨯

Identification of CAND1 as a DNA-dependent protein kinase-regulated coactivator of androgen receptor and the ARv7 splice variant

Ross A. Hamilton,
Basil Paul,
Ping Yi,
Kimal Rajapakshe,
Anil K. Panigrahi,
Sandra L. Grimm,
Cristian Coarfa,
Anna Malovannaya,
Nancy L. Weigel,
David M. Lonard

Published: May 14, 2026
https://doi.org/10.1371/journal.pone.0349130

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