YTHDF1 impacts cardiomyocyte differentiation by regulating the TET2 mRNA

Guanlin Zheng; Banban Li; Maochuan Zheng; Xiuli Tian; Zhiyong Li; Hongwei Shi; Xiaoxiao Xu; Li Fan; Yajun Hu; Liyan Jing

doi:10.1371/journal.pone.0349040

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Open Access

Peer-reviewed

Research Article

YTHDF1 impacts cardiomyocyte differentiation by regulating the TET2 mRNA

Guanlin Zheng,

Roles Funding acquisition, Investigation, Writing – original draft

Affiliations Postdoctoral Research Workstation, The Affiliated Taian City Central Hospital of Qingdao University, Taian city, Shandong Province, P.R. China, Department of Midwifery, Taishan Vocational College of Nursing, Taian city, Shandong Province, P.R. China
⨯
Banban Li,

Roles Investigation

Affiliation Postdoctoral Research Workstation, The Affiliated Taian City Central Hospital of Qingdao University, Taian city, Shandong Province, P.R. China
⨯
Maochuan Zheng,

Roles Investigation

Affiliation Department of Critical Care Medicine, The Second Affiliated Hospital of Shandong First Medical University, Taian city, Shandong Province, P.R. ‌‌‌China‌‌
⨯
Xiuli Tian,

Roles Investigation

Affiliation Department of Midwifery, Taishan Vocational College of Nursing, Taian city, Shandong Province, P.R. China
⨯
Zhiyong Li,

Roles Investigation, Writing – original draft

Affiliation Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Shanghai, P.R. China
⨯
Hongwei Shi,

Roles Investigation

Affiliation Department of Midwifery, Taishan Vocational College of Nursing, Taian city, Shandong Province, P.R. China
⨯
Xiaoxiao Xu,

Roles Investigation

Affiliation Department of Midwifery, Taishan Vocational College of Nursing, Taian city, Shandong Province, P.R. China
⨯
Li Fan,

Roles Investigation

Affiliation Department of Midwifery, Taishan Vocational College of Nursing, Taian city, Shandong Province, P.R. China
⨯
Yajun Hu ,

Roles Conceptualization, Methodology

* E-mail: 21211010015@m.fudan.edu.cn (YH); tawxjly@126.com (LJ)

Affiliation Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Shanghai, P.R. China

https://orcid.org/0009-0005-6618-7298

⨯
Liyan Jing

Roles Conceptualization, Methodology, Project administration, Supervision

* E-mail: 21211010015@m.fudan.edu.cn (YH); tawxjly@126.com (LJ)

Affiliation Department of Midwifery, Taishan Vocational College of Nursing, Taian city, Shandong Province, P.R. China
⨯

YTHDF1 impacts cardiomyocyte differentiation by regulating the TET2 mRNA

Guanlin Zheng,
Banban Li,
Maochuan Zheng,
Xiuli Tian,
Zhiyong Li,
Hongwei Shi,
Xiaoxiao Xu,
Li Fan,
Yajun Hu,
Liyan Jing

Published: May 15, 2026
https://doi.org/10.1371/journal.pone.0349040

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Cell differentiation
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Cardiomyocytes
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Messenger RNA
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Protein translation
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RNA sequencing
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Heart
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Gene expression
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Cardiac ventricles
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