Photobiomodulation for pain management during placement of the copper T 380 intrauterine device: Protocol for a randomized, double-blind controlled trial

Anna Carolina Nunes Ferraz; Maria Aparecida Traverzim; Sergio Makabe; Gláucia Gonçalves Abud Machado; Sandra Kalil Bussadori; Raquel Agnelli Mesquita-Ferrari; Cinthya Cosme Gutierrez Duran; Lara Jansiski Motta; Kristianne Porta Santos Fernandes; Anna Carolina Ratto Tempestini Horliana

doi:10.1371/journal.pone.0349031

Loading metrics

Open Access

Photobiomodulation for pain management during placement of the copper T 380 intrauterine device: Protocol for a randomized, double-blind controlled trial

Anna Carolina Nunes Ferraz ,

Contributed equally to this work with: Anna Carolina Nunes Ferraz, Maria Aparecida Traverzim, Sergio Makabe, Gláucia Gonçalves Abud Machado, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari, Cinthya Cosme Gutierrez Duran, Lara Jansiski Motta, Kristianne Porta Santos Fernandes, Anna Carolina Ratto Tempestini Horliana

Roles Funding acquisition, Methodology, Writing – original draft, Conceptualization

Current address: Postgraduate Program in Biophotonics-Medicine, 235/249 Vergueiro Street, 01525−000 São Paulo, SP, Brazil; Rua Voluntários da Pátria, 4301, Santana, Zona Norte de São Paulo, SP, Brazil

Affiliations Postgraduate Program in Biophotonics-Medicine, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil, Mandaqui Hospital Complex, São Paulo, Brazil
⨯
Maria Aparecida Traverzim ,

Contributed equally to this work with: Anna Carolina Nunes Ferraz, Maria Aparecida Traverzim, Sergio Makabe, Gláucia Gonçalves Abud Machado, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari, Cinthya Cosme Gutierrez Duran, Lara Jansiski Motta, Kristianne Porta Santos Fernandes, Anna Carolina Ratto Tempestini Horliana

Roles Data curation, Funding acquisition, Project administration, Writing – original draft, Conceptualization

Current address: Postgraduate Program in Biophotonics-Medicine, 235/249 Vergueiro Street, 01525−000 São Paulo, SP, Brazil; Rua Voluntários da Pátria, 4301, Santana, Zona Norte de São Paulo, SP, Brazil

Affiliations Postgraduate Program in Biophotonics-Medicine, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil, Mandaqui Hospital Complex, São Paulo, Brazil
⨯
Sergio Makabe ,

Contributed equally to this work with: Anna Carolina Nunes Ferraz, Maria Aparecida Traverzim, Sergio Makabe, Gláucia Gonçalves Abud Machado, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari, Cinthya Cosme Gutierrez Duran, Lara Jansiski Motta, Kristianne Porta Santos Fernandes, Anna Carolina Ratto Tempestini Horliana

Roles Funding acquisition, Project administration, Supervision, Writing – original draft, Conceptualization

Current address: Postgraduate Program in Biophotonics-Medicine, 235/249 Vergueiro Street, 01525−000 São Paulo, SP, Brazil; Rua Voluntários da Pátria, 4301, Santana, Zona Norte de São Paulo, SP, Brazil

Affiliations Postgraduate Program in Biophotonics-Medicine, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil, Mandaqui Hospital Complex, São Paulo, Brazil
⨯
Gláucia Gonçalves Abud Machado ,

Contributed equally to this work with: Anna Carolina Nunes Ferraz, Maria Aparecida Traverzim, Sergio Makabe, Gláucia Gonçalves Abud Machado, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari, Cinthya Cosme Gutierrez Duran, Lara Jansiski Motta, Kristianne Porta Santos Fernandes, Anna Carolina Ratto Tempestini Horliana

Roles Formal analysis, Investigation, Visualization, Writing – original draft

Current address: Postgraduate Program in Biophotonics-Medicine, 235/249 Vergueiro Street, 01525−000 São Paulo, SP, Brazil

Affiliation Postgraduate Program in Biophotonics-Medicine, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil
⨯
Sandra Kalil Bussadori ,

Contributed equally to this work with: Anna Carolina Nunes Ferraz, Maria Aparecida Traverzim, Sergio Makabe, Gláucia Gonçalves Abud Machado, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari, Cinthya Cosme Gutierrez Duran, Lara Jansiski Motta, Kristianne Porta Santos Fernandes, Anna Carolina Ratto Tempestini Horliana

Roles Formal analysis, Methodology, Supervision, Writing – review & editing, Conceptualization

Current address: Postgraduate Program in Biophotonics-Medicine, 235/249 Vergueiro Street, 01525−000 São Paulo, SP, Brazil; Postgraduate Program in Biophotonics-Medicine, 235/249 Vergueiro Street, 01525−000 São Paulo, SP, Brazil

Affiliations Postgraduate Program in Biophotonics-Medicine, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil, Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil
⨯
Raquel Agnelli Mesquita-Ferrari ,

Contributed equally to this work with: Anna Carolina Nunes Ferraz, Maria Aparecida Traverzim, Sergio Makabe, Gláucia Gonçalves Abud Machado, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari, Cinthya Cosme Gutierrez Duran, Lara Jansiski Motta, Kristianne Porta Santos Fernandes, Anna Carolina Ratto Tempestini Horliana

Roles Methodology, Supervision, Validation, Writing – review & editing, Conceptualization

Current address: Postgraduate Program in Biophotonics-Medicine, 235/249 Vergueiro Street, 01525−000 São Paulo, SP, Brazil; Postgraduate Program in Biophotonics-Medicine, 235/249 Vergueiro Street, 01525−000 São Paulo, SP, Brazil

Affiliations Postgraduate Program in Biophotonics-Medicine, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil, Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil
⨯
Cinthya Cosme Gutierrez Duran ,

Contributed equally to this work with: Anna Carolina Nunes Ferraz, Maria Aparecida Traverzim, Sergio Makabe, Gláucia Gonçalves Abud Machado, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari, Cinthya Cosme Gutierrez Duran, Lara Jansiski Motta, Kristianne Porta Santos Fernandes, Anna Carolina Ratto Tempestini Horliana

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – review & editing

Current address: Postgraduate Program in Biophotonics-Medicine, 235/249 Vergueiro Street, 01525−000 São Paulo, SP, Brazil

Affiliation Postgraduate Program in Biophotonics-Medicine, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil

https://orcid.org/0000-0001-9055-1524

⨯
Lara Jansiski Motta ,

Contributed equally to this work with: Anna Carolina Nunes Ferraz, Maria Aparecida Traverzim, Sergio Makabe, Gláucia Gonçalves Abud Machado, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari, Cinthya Cosme Gutierrez Duran, Lara Jansiski Motta, Kristianne Porta Santos Fernandes, Anna Carolina Ratto Tempestini Horliana

Roles Methodology, Supervision, Writing – review & editing, Formal analysis

Current address: Postgraduate Program in Biophotonics-Medicine, 235/249 Vergueiro Street, 01525−000 São Paulo, SP, Brazil

Affiliations Postgraduate Program in Biophotonics-Medicine, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil, Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil
⨯
Kristianne Porta Santos Fernandes ,

Contributed equally to this work with: Anna Carolina Nunes Ferraz, Maria Aparecida Traverzim, Sergio Makabe, Gláucia Gonçalves Abud Machado, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari, Cinthya Cosme Gutierrez Duran, Lara Jansiski Motta, Kristianne Porta Santos Fernandes, Anna Carolina Ratto Tempestini Horliana

Roles Conceptualization, Investigation, Methodology, Supervision, Validation, Writing – review & editing

Current address: Postgraduate Program in Biophotonics-Medicine, 235/249 Vergueiro Street, 01525−000 São Paulo, SP, Brazil

Affiliation Postgraduate Program in Biophotonics-Medicine, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil
⨯
Anna Carolina Ratto Tempestini Horliana

Contributed equally to this work with: Anna Carolina Nunes Ferraz, Maria Aparecida Traverzim, Sergio Makabe, Gláucia Gonçalves Abud Machado, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari, Cinthya Cosme Gutierrez Duran, Lara Jansiski Motta, Kristianne Porta Santos Fernandes, Anna Carolina Ratto Tempestini Horliana

Roles Conceptualization, Investigation, Methodology, Supervision, Validation, Writing – review & editing

* E-mail: annacrth@gmail.com

Current address: Postgraduate Program in Biophotonics-Medicine, 235/249 Vergueiro Street, 01525−000 São Paulo, SP, Brazil

Affiliation Postgraduate Program in Biophotonics-Medicine, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil

https://orcid.org/0000-0003-3476-9064

⨯

Photobiomodulation for pain management during placement of the copper T 380 intrauterine device: Protocol for a randomized, double-blind controlled trial

Anna Carolina Nunes Ferraz,
Maria Aparecida Traverzim,
Sergio Makabe,
Gláucia Gonçalves Abud Machado,
Sandra Kalil Bussadori,
Raquel Agnelli Mesquita-Ferrari,
Cinthya Cosme Gutierrez Duran,
Lara Jansiski Motta,
Kristianne Porta Santos Fernandes,
Anna Carolina Ratto Tempestini Horliana

Published: May 28, 2026
https://doi.org/10.1371/journal.pone.0349031

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Pain
Is the Subject Area "Pain" applicable to this article?

Thanks for your feedback.
Analgesics
Is the Subject Area "Analgesics" applicable to this article?

Thanks for your feedback.
Brazil
Is the Subject Area "Brazil" applicable to this article?

Thanks for your feedback.
Female contraception
Is the Subject Area "Female contraception" applicable to this article?

Thanks for your feedback.
Quality of life
Is the Subject Area "Quality of life" applicable to this article?

Thanks for your feedback.
Medical risk factors
Is the Subject Area "Medical risk factors" applicable to this article?

Thanks for your feedback.
Adverse events
Is the Subject Area "Adverse events" applicable to this article?

Thanks for your feedback.
Hemorrhage
Is the Subject Area "Hemorrhage" applicable to this article?

Thanks for your feedback.