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Open Access
Peer-reviewed
Research Article
Adjuvants MPLA and SMNP induce antiviral immunity and indirectly revert HIV-1 latency
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Jade Jansen ,
Contributed equally to this work with: Jade Jansen, Killian E. Vlaming
Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliations Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands, Amsterdam institute for infectious diseases and immunology, Amsterdam, The Netherlands
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Killian E. Vlaming ,
Contributed equally to this work with: Jade Jansen, Killian E. Vlaming
Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliations Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands, Amsterdam institute for infectious diseases and immunology, Amsterdam, The Netherlands
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Leanne C. Helgers,
Roles Investigation, Methodology, Writing – review & editing
Affiliations Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands, Amsterdam institute for infectious diseases and immunology, Amsterdam, The Netherlands
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Eva Schumacher,
Roles Resources, Writing – review & editing
Affiliations Amsterdam institute for infectious diseases and immunology, Amsterdam, The Netherlands, Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
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Tanja M. Kaptein,
Roles Investigation, Writing – review & editing
Affiliations Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands, Amsterdam institute for infectious diseases and immunology, Amsterdam, The Netherlands
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Rogier W. Sanders,
Roles Resources, Supervision, Writing – review & editing
Affiliations Amsterdam institute for infectious diseases and immunology, Amsterdam, The Netherlands, Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands, Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, United States of America
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Godelieve J. de Bree,
Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing
Affiliations Amsterdam institute for infectious diseases and immunology, Amsterdam, The Netherlands, Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
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Teunis B.H. Geijtenbeek ,
Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing
¶‡ These authors contributed equally to this work
Affiliations Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands, Amsterdam institute for infectious diseases and immunology, Amsterdam, The Netherlands
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Neeltje A. Kootstra
Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing
* E-mail: n.a.kootstra@amsterdamumc.nl
¶‡ These authors contributed equally to this work
Affiliations Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands, Amsterdam institute for infectious diseases and immunology, Amsterdam, The Netherlands
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Adjuvants MPLA and SMNP induce antiviral immunity and indirectly revert HIV-1 latency
- Jade Jansen,
- Killian E. Vlaming,
- Leanne C. Helgers,
- Eva Schumacher,
- Tanja M. Kaptein,
- Rogier W. Sanders,
- Godelieve J. de Bree,
- Teunis B.H. Geijtenbeek,
- Neeltje A. Kootstra
- Published: July 20, 2026
- https://doi.org/10.1371/journal.pone.0348959
- See the preprint