Probiotics, synbiotics and berberine in Type 2 diabetes mellitus: A systematic review, meta-analysis, and molecular dynamics simulation study

Md. Shadin; Md. Shimul Bhuia; Mohammed Alfaifi; Faisal H. Altemani; Abdullah H. Altemani; Faisal Alsenani; Na’il Saleh; Muhammad Torequl Islam

doi:10.1371/journal.pone.0348907

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Open Access

Peer-reviewed

Research Article

Probiotics, synbiotics and berberine in Type 2 diabetes mellitus: A systematic review, meta-analysis, and molecular dynamics simulation study

Md. Shadin ,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Resources, Software, Visualization, Writing – original draft, Writing – review & editing

^* mdshadin.b.pharm@gmail.com

Affiliations Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj, Bangladesh, Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, Bangladesh

https://orcid.org/0009-0000-1587-2838

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Md. Shimul Bhuia,

Roles Investigation, Validation

Affiliations Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj, Bangladesh, Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, Bangladesh
⨯
Mohammed Alfaifi,

Roles Conceptualization, Investigation, Supervision, Validation

Affiliation Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia
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Faisal H. Altemani,

Roles Investigation, Supervision, Validation

Affiliation Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia
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Abdullah H. Altemani,

Roles Investigation, Supervision, Validation

Affiliation Department of Family and Community Medicine, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia
⨯
Faisal Alsenani,

Roles Conceptualization, Investigation, Supervision, Validation

Affiliation Department of Pharmaceutical Sciences, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia
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Na’il Saleh,

Roles Investigation, Supervision, Validation

Affiliation Department of Chemistry, College of Science, United Arab Emirates University, United Arab Emirates
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Muhammad Torequl Islam

Roles Investigation, Supervision, Validation

Affiliations Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj, Bangladesh, Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, Bangladesh
⨯

Probiotics, synbiotics and berberine in Type 2 diabetes mellitus: A systematic review, meta-analysis, and molecular dynamics simulation study

Md. Shadin,
Md. Shimul Bhuia,
Mohammed Alfaifi,
Faisal H. Altemani,
Abdullah H. Altemani,
Faisal Alsenani,
Na’il Saleh,
Muhammad Torequl Islam

Published: May 29, 2026
https://doi.org/10.1371/journal.pone.0348907

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HbA1c
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Type 2 diabetes
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