Genetic variants in the leptin-melanocortin pathway and their joint effects with physical activity and sleep duration on risk of childhood obesity

Xiaotong Liang; Shun Pan; Jiting Ji; Yuying Deng; Miao Chen; Ziwei Huang; Jiaru Deng; Min Chen; Tiantian Xiong; Jianping Liang; Li Liu

doi:10.1371/journal.pone.0348694

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Open Access

Peer-reviewed

Research Article

Genetic variants in the leptin-melanocortin pathway and their joint effects with physical activity and sleep duration on risk of childhood obesity

Xiaotong Liang,

Roles Conceptualization, Formal analysis, Methodology, Visualization, Writing – original draft

Affiliation Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China
⨯
Shun Pan,

Roles Data curation, Investigation

Affiliation Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China
⨯
Jiting Ji,

Roles Data curation, Investigation

Affiliation Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China
⨯
Yuying Deng,

Roles Formal analysis, Validation

Affiliation Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China
⨯
Miao Chen,

Roles Formal analysis, Validation

Affiliation Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China
⨯
Ziwei Huang,

Roles Formal analysis, Validation

Affiliation Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China
⨯
Jiaru Deng,

Roles Investigation

Affiliation Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China
⨯
Min Chen,

Roles Investigation

Affiliation Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China
⨯
Tiantian Xiong,

Roles Investigation

Affiliation Department of Occupational Health, Shenzhen Bao’an District Public Health Center, Shenzhen, China‌‌
⨯
Jianping Liang ,

Roles Investigation, Project administration

* E-mail: 413590176@qq.com (JL); pupuliu919@163.com (LL)

Affiliation Department of School Health, Guangzhou Health Care Promotion Center for Primary and Middle Schools, Guangzhou, China
⨯
Li Liu

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: 413590176@qq.com (JL); pupuliu919@163.com (LL)

Affiliation Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China

https://orcid.org/0000-0001-8888-7117

⨯

Genetic variants in the leptin-melanocortin pathway and their joint effects with physical activity and sleep duration on risk of childhood obesity

Xiaotong Liang,
Shun Pan,
Jiting Ji,
Yuying Deng,
Miao Chen,
Ziwei Huang,
Jiaru Deng,
Min Chen,
Tiantian Xiong,
Jianping Liang

Published: May 15, 2026
https://doi.org/10.1371/journal.pone.0348694

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