Inhibition of purine nucleoside and nucleobase transporters by tyrosine kinase inhibitors

Nayiar Shahid; Chan H. Kim; Kerrylei B. Jabilona; Khanh H. Nguyen; Nicholas M. Ruel; James R. Hammond

doi:10.1371/journal.pone.0348426

Loading metrics

Open Access

Peer-reviewed

Research Article

Inhibition of purine nucleoside and nucleobase transporters by tyrosine kinase inhibitors

Nayiar Shahid,

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmacology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada
⨯
Chan H. Kim,

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmacology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada
⨯
Kerrylei B. Jabilona,

Roles Formal analysis, Investigation

Affiliation Department of Pharmacology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada
⨯
Khanh H. Nguyen,

Roles Investigation, Supervision

Affiliation Department of Pharmacology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada
⨯
Nicholas M. Ruel,

Roles Formal analysis, Investigation, Supervision, Writing – review & editing

Affiliation Department of Pharmacology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada
⨯
James R. Hammond

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: james.hammond@ualberta.ca

Affiliation Department of Pharmacology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada

https://orcid.org/0000-0002-9006-7529

⨯

Inhibition of purine nucleoside and nucleobase transporters by tyrosine kinase inhibitors

Nayiar Shahid,
Chan H. Kim,
Kerrylei B. Jabilona,
Khanh H. Nguyen,
Nicholas M. Ruel,
James R. Hammond

Published: May 15, 2026
https://doi.org/10.1371/journal.pone.0348426

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Nucleosides
Is the Subject Area "Nucleosides" applicable to this article?

Thanks for your feedback.
Nucleobases
Is the Subject Area "Nucleobases" applicable to this article?

Thanks for your feedback.
Drug interactions
Is the Subject Area "Drug interactions" applicable to this article?

Thanks for your feedback.
Purines
Is the Subject Area "Purines" applicable to this article?

Thanks for your feedback.
Cell viability testing
Is the Subject Area "Cell viability testing" applicable to this article?

Thanks for your feedback.
Oils
Is the Subject Area "Oils" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Tyrosine kinases
Is the Subject Area "Tyrosine kinases" applicable to this article?

Thanks for your feedback.