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Open Access

Peer-reviewed

Research Article

Response surface methodology to optimize the green synthesis process of cefotaxime sodium: Collaborative improvement of yield, crystal form control and environmental benefits

Wang Yizhang,

Roles Conceptualization

Affiliation Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region, China

https://orcid.org/0009-0007-2467-0024

⨯
Li Jing,

Roles Investigation

Affiliation Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region, China
⨯
Yang Mingxi,

Roles Investigation

Affiliation Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region, China
⨯
Ou Shiqiang,

Roles Resources

Affiliation Guangxi Kelun Pharmaceutical Co., Ltd., Guilin, Guangxi Zhuang Autonomous Region, China
⨯
Liu Hao,

Roles Investigation

Affiliation Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region, China
⨯
Xie Peng ,

Roles Resources

* E-mail: 58713645@qq.com (XP); 23207041022@stu.glmu.edu.cn (ZK)

Affiliation Guangxi Kelun Pharmaceutical Co., Ltd., Guilin, Guangxi Zhuang Autonomous Region, China
⨯
Zhu Kaimei

Roles Supervision

* E-mail: 58713645@qq.com (XP); 23207041022@stu.glmu.edu.cn (ZK)

Affiliation Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region, China
⨯

Response surface methodology to optimize the green synthesis process of cefotaxime sodium: Collaborative improvement of yield, crystal form control and environmental benefits

Wang Yizhang,
Li Jing,
Yang Mingxi,
Ou Shiqiang,
Liu Hao,
Xie Peng,
Zhu Kaimei

x

Published: May 14, 2026
https://doi.org/10.1371/journal.pone.0348350

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